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Cited 2 time in webofscience Cited 2 time in scopus
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Association between the progression of immunoglobulin A nephropathy and a controlled status of hypertension in the first year after diagnosisopen access

Authors
Oh, Tae RyomChoi, Hong SangOh, Se WonOh, JieunLee, Dong WonKim, Chang SeongMa, Seong KwonKim, Soo WanBae, Eun HuiKorean GlomeruloNEphritis Study Group
Issue Date
Jan-2022
Publisher
대한내과학회
Keywords
Hypertension; Immunoglobulin A nephropathy; Glomerulonephritis; Blood pressure
Citation
The Korean Journal of Internal Medicine, v.37, no.1, pp 146 - 153
Pages
8
Indexed
SCIE
SCOPUS
KCI
Journal Title
The Korean Journal of Internal Medicine
Volume
37
Number
1
Start Page
146
End Page
153
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55092
DOI
10.3904/kjim.2020.205
ISSN
1226-3303
2005-6648
Abstract
Background/Aims Hypertension is considered a risk factor in immunoglobulin A nephropathy (IgAN). However, after IgAN diagnosis, the relationship between early blood pressure control and renal prognosis remains unclear. This study aimed to analyze the association between the prognosis of IgAN patients and a controlled status of hypertension within the first year of IgAN diagnosis. Methods We retrospectively analyzed 2,945 patients diagnosed with IgAN by renal biopsy. The patients were divided into ‘normal,’ ‘new-onset,’ ‘well-controlled,’ and ‘poorly-controlled’ groups using blood pressure data from two consecutive measurements performed within a year. The Kaplan-Meier survival analysis and Cox proportional-hazards regression model were used to survey the independent association between recovery from hypertension and the risk of IgAN progression. The primary endpoint was IgAN progression defined as the initiation of dialysis or kidney transplantation. Results Before IgAN diagnosis, 1,239 patients (42.1%) had been diagnosed with hypertension. In the fully adjusted Cox proportional-hazards models, the risk of IgAN progression increased by approximately 1.7-fold for the prevalence of hypertension. In the subgroup analyses, the ‘well-controlled’ group showed a statistically significant risk of IgAN progression (hazard ratio [HR], 3.19; 95% confidence interval [CI], 1.103 to 9.245; p = 0.032). Moreover, the ‘new-onset’ and ‘poorly-controlled’ groups had an increased risk of IgAN progression compared to the ‘normal’ group (HR, 2.58; 95% CI, 1.016 to 6.545; p = 0.046 and HR, 3.85;95% CI, 1.541 to 9.603; p = 0.004, respectively). Conclusions Although hypertension was well-controlled in the first year after IgAN diagnosis, it remained a risk factor for IgAN progression.
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Oh, Se Won
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
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