Detailed Information

Cited 21 time in webofscience Cited 25 time in scopus
Metadata Downloads

Changes in Metabolic Syndrome Status are Associated With Altered Risk of Pancreatic Cancer: A Nationwide Cohort Study

Authors
Park, Joo-HyunHan, KyungdoHong, Jung YongPark, Young SukHur, Kyu YeonKang, GunseogPark, Joon Oh
Issue Date
Feb-2022
Publisher
W. B. Saunders Co., Ltd.
Keywords
Pancreatic Neoplasms; Risk Factors; Malignant Tumor; Prevention
Citation
Gastroenterology, v.162, no.2, pp 509 - +
Indexed
SCIE
SCOPUS
Journal Title
Gastroenterology
Volume
162
Number
2
Start Page
509
End Page
+
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55218
DOI
10.1053/j.gastro.2021.09.070
ISSN
0016-5085
1528-0012
Abstract
BACKGROUND AND AIMS: Metabolic syndrome (MetS) is reversible; however, the effect of changes in MetS status on pancreatic cancer risk is unknown. We aimed to investigate the effects of changes and persistence in MetS status on pancreatic cancer risk. METHODS: This nationwide cohort study included 8,203,492 adults without cancer who underwent 2 consecutive biennial health screenings provided by the Korean National Health Insurance System between 2009 and 2012 and were followed up until 2017. MetS was defined as the presence of 3 of its 5 components, which were evaluated at 2 consecutive biennial health screenings. Participants were categorized into the MetS-free, MetS-recovered, MetS-developed, or MetS-persistent group. Multivariable Cox proportional hazards regression models were used. RESULTS: During the 40,464,586 person-years of follow-up (median, 5.1 years), 8010 individuals developed pancreatic cancer. Compared with the MetS-free group, the MetS-persistent group had the highest risk of pancreatic cancer (hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.23-1.37), followed by the MetS-developed group (HR, 1.17; 95% CI, 1.09-1.25) and the MetS-recovered group (HR, 1.12; 95% CI, 1.04-1.21) after adjusting for potential confounders (P for trend <.001). The MetS-recovered group was associated with a lower risk of pancreatic cancer than that in the MetS-persistent group (P < .001). The association between changes in MetS status and pancreatic cancer risk did not differ according to sex or obesity (all P for interactions >.05). CONCLUSIONS: In this study, recovering from MetS was associated with a reduced risk of pancreatic cancer compared with persistent MetS, suggesting that pancreatic cancer risk can be altered by changes in MetS.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Family Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Joo Hyun photo

Park, Joo Hyun
Ansan Hospital (Department of Family Medicine, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE