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Cited 6 time in webofscience Cited 7 time in scopus
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The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome

Authors
Kim, Ji-EunKim, Jin-SunJo, Min-JeeCho, EunjungAhn, Shin-YoungKwon, Young-JooKo, Gang-Jee
Issue Date
Jan-2022
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
adipokine; metabolic syndrome; glucose intolerance; lipid metabolism
Citation
Molecules, v.27, no.2
Indexed
SCIE
SCOPUS
Journal Title
Molecules
Volume
27
Number
2
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55267
DOI
10.3390/molecules27020334
ISSN
1420-3049
Abstract
Metabolic syndrome is a cluster of metabolic indicators that increase the risk of diabetes and cardiovascular diseases. Visceral obesity and factors derived from altered adipose tissue, adipokines, play critical roles in the development of metabolic syndrome. Although the adipokines leptin and adiponectin improve insulin sensitivity, others contribute to the development of glucose intolerance, including visfatin, fetuin-A, resistin, and plasminogen activator inhibitor-1 (PAI-1). Leptin and adiponectin increase fatty acid oxidation, prevent foam cell formation, and improve lipid metabolism, while visfatin, fetuin-A, PAI-1, and resistin have pro-atherogenic properties. In this review, we briefly summarize the role of various adipokines in the development of metabolic syndrome, focusing on glucose homeostasis and lipid metabolism.
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4. Research institute > Institute of Convergence New Drug Development > 1. Journal Articles
2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles

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