Efficacy and safety of a thermosensitive hydrogel for endoscopic submucosal dissection: An in vivo swine study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Han Jo | - |
dc.contributor.author | Choi, Hyuk Soon | - |
dc.contributor.author | Bang, Eun Ju | - |
dc.contributor.author | Lee, Kang Won | - |
dc.contributor.author | Kim, Sang Hyun | - |
dc.contributor.author | Lee, Jae Min | - |
dc.contributor.author | Kim, Eun Sun | - |
dc.contributor.author | Keum, Bora | - |
dc.contributor.author | Jeen, Yoon Tae | - |
dc.contributor.author | Lee, Hong Sik | - |
dc.contributor.author | Chun, Hoon Jai | - |
dc.contributor.author | Jeong, Seung | - |
dc.contributor.author | Kim, Jong Hyuk | - |
dc.date.accessioned | 2022-02-28T02:40:14Z | - |
dc.date.available | 2022-02-28T02:40:14Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55320 | - |
dc.description.abstract | Injectable thermo-sensitive chitosan hydrogels have recently been developed for the use of submucosal fluids in endoscopic submucosal dissections (ESD). This study aimed to investigate the efficacy and safety of chitosan hydrogels during ESD. Submucosal fluids were administered as follows: 0.9% normal saline (NS), 0.4% hyaluronic acid (HA) and chitosan/beta-glycerophosphate (CS/GP) hydrogel. Each solution was administered twice into the stomach and colon of a pig, with a total of 72 ESD procedures performed on 12 pigs. The injected volume and procedure-related parameters were recorded and analyzed. ESDs that created ulcers after 7 days were histologically compared. All ESD specimens were resected en bloc. The total injected volumes during ESD of the stomach (NS, 16.09 +/- 3.27 vs. HA, 11.17 +/- 2.32 vs. CS/GP, 9.44 +/- 2.33; p<0.001) and colon (NS, 9.17 +/- 1.80 vs. HA, 6.67 +/- 1.50 vs. CS/GP, 6.75 +/- 1.57; p = 0.001) were significantly different. Hydrogel showed significant differences from normal saline in terms of fluid power (mm(2)/vol; NS, 35.70 +/- 9.00 vs. CS/GP 57.48 +/- 20.77; p = 0.001) and consumption rate (vol/min; NS, 2.59 +/- 0.86 vs. CS/GP, 1.62 +/- 0.65; p = 0.013) in the stomach. Histological examination revealed preserved muscularis propria, although the chitosan hydrogel resulted in a partial inflammatory response, with a hypertrophied submucosal layer. Chitosan hydrogel was found to be superior to normal saline, with an efficacy similar to that of hyaluronic acid. Nonetheless, long-term histological changes should be evaluated before clinical implementation. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Public Library of Science | - |
dc.title | Efficacy and safety of a thermosensitive hydrogel for endoscopic submucosal dissection: An in vivo swine study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1371/journal.pone.0260458 | - |
dc.identifier.scopusid | 2-s2.0-85121054158 | - |
dc.identifier.wosid | 000755037200029 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.16, no.12 | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 16 | - |
dc.citation.number | 12 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | PHOTOCROSSLINKABLE CHITOSAN HYDROGEL | - |
dc.subject.keywordPlus | INJECTION SOLUTION | - |
dc.subject.keywordPlus | MUCOSAL RESECTION | - |
dc.subject.keywordPlus | GLYCEROPHOSPHATE | - |
dc.subject.keywordPlus | CANCER | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.