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The clinical impact of strict criteria for active surveillance of prostate cancer in Korean population: Results from a prospective cohort

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dc.contributor.authorSuh, Jungyo-
dc.contributor.authorYuk, Hyeong Dong-
dc.contributor.authorKang, Minyong-
dc.contributor.authorTae, Bum Sik-
dc.contributor.authorKu, Ja Hyeon-
dc.contributor.authorKim, Hyeon Hoe-
dc.contributor.authorKwak, Cheol-
dc.contributor.authorJeong, Chang Wook-
dc.date.accessioned2022-02-28T02:40:18Z-
dc.date.available2022-02-28T02:40:18Z-
dc.date.issued2021-07-
dc.identifier.issn2466-0493-
dc.identifier.issn2466-054X-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55324-
dc.description.abstractPurpose To evaluate the clinical impact of strict selection criteria for active surveillance (AS) of prostate cancer in a Korean population. Materials and Methods A single-center, prospectively collected AS cohort from December 2016 to February 2019 was used. Following pre-determined criteria, patients were categorized into “strict AS” and “non-strict AS” groups. Clinicopathological progression-free survival (PFS) and treatment-free survival (TFS) of the two groups were compared using the Kaplan–Meier curve and log-rank test. Age-adjusted hazard ratios for clinicopathological progression was calculated using Cox proportional regression analysis. Results Of 54 eligible patients, 25 and 29 were assigned to “strict AS” and “non-strict AS,” respectively. Clinicopathological progression and definitive treatment rates were 24.0% (6 of 25 patients) vs. 51.7% (15 of 29 patients) and 32.0% (8 of 25 patients) vs. 62.1% (18 of 29 patients) in “strict AS” and “non-strict AS” groups. Progress to high-risk cancer (pathologic T3 or surgical Gleason Grade 2 over) in radical prostatectomy was higher in “non-strict AS” than “strict AS”. PFS (mean 34.6±2.9 mo vs. 22.6±2.7 mo; p=0.025) and TFS (mean 31.8±3.2 mo vs. 19.6±2.4 mo; p=0.018) favor the “strict AS” group than “non-strict AS” group. Age-adjusted hazard ratio for clinicopathological progression of strict criteria was 0.36 (95% confidence interval, 0.14–0.94; p=0.04). Conclusions PFS and TFS were better in the “strict AS” group than in the “non-strict AS” group. This finding should be informed to relevant patients during decision making and considered in Korean guidelines.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisher대한비뇨기과학회-
dc.titleThe clinical impact of strict criteria for active surveillance of prostate cancer in Korean population: Results from a prospective cohort-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.4111/icu.20200504-
dc.identifier.scopusid2-s2.0-85109538432-
dc.identifier.wosid000753897700008-
dc.identifier.bibliographicCitationInvestigative and Clinical Urology, v.62, no.4, pp 430 - 437-
dc.citation.titleInvestigative and Clinical Urology-
dc.citation.volume62-
dc.citation.number4-
dc.citation.startPage430-
dc.citation.endPage437-
dc.type.docTypeArticle-
dc.identifier.kciidART002736052-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaUrology & Nephrology-
dc.relation.journalWebOfScienceCategoryUrology & Nephrology-
dc.subject.keywordPlusMEN-
dc.subject.keywordPlusMORTALITY-
dc.subject.keywordPlusWORLDWIDE-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordPlusSELECTION-
dc.subject.keywordPlusSTAGE-
dc.subject.keywordAuthorActive surveillance-
dc.subject.keywordAuthorPatient selection-
dc.subject.keywordAuthorProstate neoplasms-
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