Detailed Information

Cited 0 time in webofscience Cited 17 time in scopus
Metadata Downloads

Prospective evaluation of changes in tumor size and tumor metabolism in patients with advanced gastric cancer undergoing chemotherapy: Association and clinical implication

Authors
Park S.Ha S.Kwon H.W.Kim W.H.Kim T.-Y.Oh D.-Y.Cheon G.J.Bang Y.-J.
Issue Date
2017
Publisher
Society of Nuclear Medicine Inc.
Keywords
Chemotherapy; Metabolism; Positron-emission tomography; Prognosis; Stomach neoplasm
Citation
Journal of Nuclear Medicine, v.58, no.6, pp.899 - 904
Indexed
SCIE
SCOPUS
Journal Title
Journal of Nuclear Medicine
Volume
58
Number
6
Start Page
899
End Page
904
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5650
DOI
10.2967/jnumed.116.182675
ISSN
0161-5505
Abstract
chemotherapy remains unclear. We aimed to evaluate response of tumor size and metabolism in AGC during chemotherapy and to reveal the relationship between them in view of their impact on patient survival. Methods: We prospectively enrolled patients with AGC before the initiation of first-line palliative chemotherapy. Using baseline and follow-up contrast-enhanced CT and 18F-FDG PET, we assessed the tumor diameter, SUVmax, and total lesion glycolysis in each lesion and their changes during chemotherapy at the same time. We included all lesions with the maximal longest diameters over 1 cm on CT, and each lesion was evaluated by matched 18F-FDG PET. We analyzed the association between changes in tumor metabolism and tumor size and performed outcome analysis on overall survival (OS) and progression-free survival (PFS). Results: Seventy-four patients were enrolled, and the number of all lesions included in this study was 620. Compared with adenocarcinomas, poorly cohesive carcinomas demonstrated lower SUVmax irrespective of tumor size (P , 0.001). Human epidermal growth factor receptor 2 (HER2)-positive tumors showed higher SUVmax than HER2-negative tumors (P 5 0.002). The changes in SUVmax due to chemotherapy had a linear correlation with the changes in tumor size of each lesion, and a 30% tumor size reduction was associated with a 50% SUVmax reduction (P , 0.001). Total lesion glycolysis changes also correlated with tumor size changes (P , 0.001). Better OS and PFS were obtained in patients with both tumor size and SUVmax reduction than in patients with either size or SUVmax reduction only (OS, P 5 0.003; PFS, P 5 0.038). Conclusion: Changes in tumor metabolism induced by chemotherapy correlated with changes in tumor size in AGC. Considering both changes in metabolism and size could help predict a more accurate prognosis for AGC patients undergoing chemotherapy. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Nuclear Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kwon, Hyun Woo photo

Kwon, Hyun Woo
Anam Hospital (Department of Nuclear Medicine, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE