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Impact of Young Age at Diagnosis on Survival in Patients with Surgically Treated Renal Cell Carcinoma: A Multicenter Study

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dc.contributor.authorKang, Ho Won-
dc.contributor.authorSeo, Sung Pil-
dc.contributor.authorKim, Won Tae-
dc.contributor.authorYun, Seok Joong-
dc.contributor.authorLee, Sang-Cheol-
dc.contributor.authorKim, Wun-Jae-
dc.contributor.authorHwang, Eu Chang-
dc.contributor.authorKang, Seok Ho-
dc.contributor.authorHong, Sung-Hoo-
dc.contributor.authorChung, Jinsoo-
dc.contributor.authorKwon, Tae Gyun-
dc.contributor.authorKim, Hyeon Hoe-
dc.contributor.authorKwak, Cheol-
dc.contributor.authorByun, Seok-Soo-
dc.contributor.authorKim, Yong-June-
dc.date.available2020-11-02T10:41:56Z-
dc.date.issued2016-12-
dc.identifier.issn1011-8934-
dc.identifier.issn1598-6357-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5806-
dc.description.abstractThe prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n= 541), middle-age (>= 40 and < 60 years, n= 2,551), and old age (>= 60 years, n= 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisher대한의학회-
dc.titleImpact of Young Age at Diagnosis on Survival in Patients with Surgically Treated Renal Cell Carcinoma: A Multicenter Study-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.3346/jkms.2016.31.12.1976-
dc.identifier.scopusid2-s2.0-84995687247-
dc.identifier.wosid000390104800019-
dc.identifier.bibliographicCitationJournal of Korean Medical Science, v.31, no.12, pp 1976 - 1982-
dc.citation.titleJournal of Korean Medical Science-
dc.citation.volume31-
dc.citation.number12-
dc.citation.startPage1976-
dc.citation.endPage1982-
dc.type.docTypeArticle-
dc.identifier.kciidART002173146-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPlusINDEPENDENT PROGNOSTIC-FACTOR-
dc.subject.keywordPlusCANCER-SPECIFIC SURVIVAL-
dc.subject.keywordPlusOLD-
dc.subject.keywordPlusNEPHRECTOMY-
dc.subject.keywordPlusEXPERIENCE-
dc.subject.keywordPlusGUIDELINE-
dc.subject.keywordPlusUPDATE-
dc.subject.keywordPlusADULTS-
dc.subject.keywordPlusWOMEN-
dc.subject.keywordAuthorRenal Cell Carcinoma-
dc.subject.keywordAuthorNephrectomy-
dc.subject.keywordAuthorAge-
dc.subject.keywordAuthorRecurrence-
dc.subject.keywordAuthorSurvival-
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Anam Hospital (Department of Urology, Anam Hospital)
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