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Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder

Authors
Won, EunsooKang, JuneKim, AramChoi, SunyoungHan, Kyu-ManTae, Woo SukChang, Hun SooSon, Kyu RiGreenberg, TsafrirJoe, Sook-HaengLee, Min-SooHam, Byung-Joo
Issue Date
Oct-2016
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Major depressive disorder; Hippocampus; Parahippocampal cingulum; BclI C/G (rs41423247)
Citation
PSYCHONEUROENDOCRINOLOGY, v.72, pp 147 - 155
Pages
9
Indexed
SCI
SCIE
SCOPUS
Journal Title
PSYCHONEUROENDOCRINOLOGY
Volume
72
Start Page
147
End Page
155
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6000
DOI
10.1016/j.psyneuen.2016.07.008
ISSN
0306-4530
Abstract
We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression. (C) 2016 Elsevier Ltd. All rights reserved.
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Han, Kyu-Man
Anam Hospital (Department of Psychiatry, Anam Hospital)
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