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Cited 88 time in webofscience Cited 103 time in scopus
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Advanced Circadian Phase in Mania and Delayed Circadian Phase in Mixed Mania and Depression Returned to Normal after Treatment of Bipolar Disorderopen access

Authors
Moon, Joung-HoCho, Chul-HyunSon, Gi HoonGeum, DonghoChung, SooyoungKim, HyunKang, Seung-GulPark, Young-MinYoon, Ho-KyoungKim, LeenJee, Hee-JungAn, HyongginKripke, Daniel. F.Lee, Heon-Jeong
Issue Date
Sep-2016
Publisher
ELSEVIER SCIENCE BV
Keywords
Circadian rhythm; Bipolar disorders; Phase shift; Circadian dysregulation
Citation
EBIOMEDICINE, v.11, pp 285 - 295
Pages
11
Indexed
SCOPUS
ESCI
Journal Title
EBIOMEDICINE
Volume
11
Start Page
285
End Page
295
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6160
DOI
10.1016/j.ebiom.2016.08.019
ISSN
2352-3964
2352-3964
Abstract
Disturbances in circadian rhythms have been suggested as a possible cause of bipolar disorder (BD). Included in this study were 31 mood episodes of 26 BD patients, and 18 controls. Circadian rhythms of BD were evaluated at admission, at 2- week intervals during hospitalization, and at discharge. All participants wore wrist actigraphs during the studies. Saliva and buccal cells were obtained at 8:00, 11:00, 15:00, 19:00, and 23:00 for two consecutive days. Collected saliva and buccal cells were used for analysis of the cortisol and gene circadian rhythm, respectively. Circadian rhythms had different phases during acute mood episodes of BD compared to recovered states. In 23 acute manic episodes, circadian phases were similar to 7 hour advanced (equivalent to similar to 17 hour delayed). Phases of 21 out of these 23 cases returned to normal by similar to 7 hour delay along with treatment, but two out of 23 cases returned to normal by similar to 17 hour advance. In three cases of mixedmanic episodes, the phases were similar to 6-7 hour delayed. For five cases of depressive episodes, circadian rhythms phases were similar to 4-5 hour delayed. After treatment, circadian phases resembled those of healthy controls. Circadian misalignment due to circadian rhythm phase shifts might be a pathophysiological mechanism of BD. (C) 2016 The Authors. Published by Elsevier B.V.
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Cho, Chul-Hyun
Anam Hospital (Department of Psychiatry, Anam Hospital)
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