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Cited 43 time in webofscience Cited 48 time in scopus
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Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder

Authors
Won, E.Choi, S.Kang, J.Kim, A.Han, K-MChang, H. S.Tae, W. S.Son, K. R.Joe, S-HLee, M-SHam, B-J
Issue Date
9-Aug-2016
Publisher
NATURE PUBLISHING GROUP
Citation
TRANSLATIONAL PSYCHIATRY, v.6
Indexed
SCIE
SCOPUS
Journal Title
TRANSLATIONAL PSYCHIATRY
Volume
6
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6182
DOI
10.1038/tp.2016.137
ISSN
2158-3188
Abstract
Previous evidence suggests that the serotonin transporter gene (SLC6A4) is associated with the structure of brain regions that are critically involved in dysfunctional limbic-cortical network activity associated with major depressive disorder (MDD). Diffusion tensor imaging (DTI) and tract-based spatial statistics were used to investigate changes in white matter integrity in patients with MDD compared with healthy controls. A possible association between structural alterations in white matter tracts and DNA methylation of the SLC6A4 promoter region was also assessed. Thirty-five medication-naive patients with MDD (mean age: 40.34, male/female: 10/25) and age, gender and education level matched 49 healthy controls (mean age: 41.12, male/female: 15/34) underwent DTI. SLC6A4 DNA methylation was also measured at five CpG sites of the promoter region, and the cell type used was whole-blood DNA. Patients with MDD had significantly lower fractional anisotropy (FA) values for the genu of the corpus callosum and body of the corpus callosum than that in healthy controls (family-wise error corrected, P<0.01). Significant inverse correlations were observed between SLC6A4 DNA methylation and FA (CpG3, Pearson's correlation: r = -0.493, P = 0.003) and axial diffusivity (CpG3, Pearson's correlation: r = -0.478, P = 0.004) values of the body of the corpus callosum in patients with MDD. These results contribute to evidence indicating an association between epigenetic gene regulation and structural brain alterations in depression. Moreover, we believe this is the first report of a correlation between DNA methylation of the SLC6A4 promoter region and white matter integrity in patients with MDD.
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Han, Kyu-Man
Anam Hospital (Department of Psychiatry, Anam Hospital)
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