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Iron chelator-induced apoptosis via the ER stress pathway in gastric cancer cells

Authors
Kim, Jung LimLee, Dae-HeeNa, Yoo JinKim, Bo RamJeong, Yoon A.Lee, Sun IlKang, SangheeJoung, Sung YupLee, Suk-YoungOh, Sang CheulMin, Byung Wook
Issue Date
Jul-2016
Publisher
SAGE PUBLICATIONS LTD
Keywords
Iron chelator; Gastric cancer; ER stress; JNK
Citation
TUMOR BIOLOGY, v.37, no.7, pp.9709 - 9719
Indexed
SCIE
SCOPUS
Journal Title
TUMOR BIOLOGY
Volume
37
Number
7
Start Page
9709
End Page
9719
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6260
DOI
10.1007/s13277-016-4878-4
ISSN
1010-4283
Abstract
Many reports have shown the anticancer effects of iron deficient on cancer cells, but the effects of iron-chelators on gastric cancer have not been clearly elucidated. Recently, we reported that iron chelators induced an antiproliferative effect in human malignant lymphoma and myeloid leukemia cells. In the present study, we investigated the antitumor activity of these two iron-chelating agents, deferoxamine (DFO) and deferasirox (DFX), with gastric cancer cell lines, and their apoptosis-inducing effects as the potential mechanism. We found that iron chelators displayed significant antiproliferative activity in human gastric cancer cell lines, which may be attributed to their induction of G1 phase arrest and apoptosis. We also found that iron chelators induced reactive oxygen species (ROS) production, resulting in the activation of both c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in gastric cancer cells. Taken together, our data suggest that iron chelators induced apoptosis in gastric cancer, involving ROS formation ER stress and JNK activation.
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2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
3. Graduate School > Graduate School > 1. Journal Articles
4. Research institute > Institute of Convergence New Drug Development > 1. Journal Articles

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Min, Byung Wook
Guro Hospital (Department of Colon and Rectal Surgery, Guro Hospital)
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