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Cited 30 time in webofscience Cited 31 time in scopus
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DA-1229, a dipeptidyl peptidase IV inhibitor, protects against renal injury by preventing podocyte damage in an animal model of progressive renal injury

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dc.contributor.authorLee, Jee Eun-
dc.contributor.authorKim, Jung Eun-
dc.contributor.authorLee, Mi Hwa-
dc.contributor.authorSong, Hye Kyoung-
dc.contributor.authorGhee, Jung Yeon-
dc.contributor.authorKang, Young Sun-
dc.contributor.authorMin, Hye Sook-
dc.contributor.authorKim, Hyun Wook-
dc.contributor.authorCha, Jin Joo-
dc.contributor.authorHan, Jee Young-
dc.contributor.authorHan, Sang Youb-
dc.contributor.authorCha, Dae Ryong-
dc.date.available2020-11-02T12:41:26Z-
dc.date.issued2016-05-
dc.identifier.issn0023-6837-
dc.identifier.issn1530-0307-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6480-
dc.description.abstractAlthough dipeptidyl peptidase IV (DPPIV) inhibitors are known to have renoprotective effects, the mechanism underlying these effects has remained elusive. Here we investigated the effects of DA-1229, a novel DPPIV inhibitor, in two animal models of renal injury including db/db mice and the adriamycin nephropathy rodent model of chronic renal disease characterized by podocyte injury. For both models, DA-1229 was administered at 300 mg/kg/day. DPPIV activity in the kidney was significantly higher in diabetic mice compared with their nondiabetic controls. Although DA-1229 did not affect glycemic control or insulin resistance, DA-1229 did improve lipid profiles, albuminuria and renal fibrosis. Moreover, DA-1229 treatment resulted in decreased urinary excretion of nephrin, decreased circulating and kidney DPPIV activity, and decreased macrophage infiltration in the kidney. In adriamycin-treated mice, DPPIV activity in the kidney and urinary nephrin loss were both increased, whereas glucagon-like peptide-1 concentrations were unchanged. Moreover, DA-1229 treatment significantly improved proteinuria, renal fibrosis and inflammation associated with decreased urinary nephrin loss, and kidney DPP4 activity. In cultured podocytes, DA-1229 restored the high glucose/angiotensin II-induced increase of DPPIV activity and preserved the nephrin levels in podocytes. These findings suggest that activation of DPPIV in the kidney has a role in the progression of renal disease, and that DA-1229 may exert its renoprotective effects by preventing podocyte injury.-
dc.format.extent14-
dc.language영어-
dc.language.isoENG-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleDA-1229, a dipeptidyl peptidase IV inhibitor, protects against renal injury by preventing podocyte damage in an animal model of progressive renal injury-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1038/labinvest.2016.34-
dc.identifier.scopusid2-s2.0-84964745293-
dc.identifier.wosid000374918400006-
dc.identifier.bibliographicCitationLABORATORY INVESTIGATION, v.96, no.5, pp 547 - 560-
dc.citation.titleLABORATORY INVESTIGATION-
dc.citation.volume96-
dc.citation.number5-
dc.citation.startPage547-
dc.citation.endPage560-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalResearchAreaPathology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.relation.journalWebOfScienceCategoryPathology-
dc.subject.keywordPlusGLUCAGON-LIKE PEPTIDE-1-
dc.subject.keywordPlusIMPROVES INSULIN-RESISTANCE-
dc.subject.keywordPlusMOLECULAR-MECHANISMS-
dc.subject.keywordPlusDPP-4 INHIBITION-
dc.subject.keywordPlusPROTEINURIA-
dc.subject.keywordPlusKIDNEY-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusNEPHROPATHY-
dc.subject.keywordPlusSITAGLIPTIN-
dc.subject.keywordPlusEXPRESSION-
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Cha, Dae Ryong
Ansan Hospital (Department of Nephrology and Hypertension, Ansan Hospital)
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