BCLC stage B is a better designation for single large hepatocellular carcinoma than BCLC stage A
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Jung, Chang Ho | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Kim, Tae Hyung | - |
dc.contributor.author | Yoo, Yang Jae | - |
dc.contributor.author | Kang, Seong Hee | - |
dc.contributor.author | Yim, Sun Young | - |
dc.contributor.author | Suh, Sang Jun | - |
dc.contributor.author | An, Hyunggin | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.contributor.author | Um, Soon Ho | - |
dc.date.available | 2020-11-02T13:41:23Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.issn | 1440-1746 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6777 | - |
dc.description.abstract | Background and Aim: Although the Barcelona Clinic Liver Cancer (BCLC) staging system is widely used for hepatocellular carcinoma (HCC) staging, the most appropriate BCLC stage designation for single large HCC (SLHCC, single nodule > 5 cm) remains controversial. This study investigated the prognosis of patients with SLHCC. Methods: Patients with newly diagnosed HCCs (BCLC stages A or B) were classified according to tumor burden: group 1, a single nodule > 2 and ≤ 5 cm or two or three nodules ≤ 3 cm; group 2, a single nodule > 5 cm; and group 3, two or three nodules > 3 cm or > 3 nodules. Survival analysis was performed according to tumor stage, treatment type, and Child–Pugh grade. Results: A total of 1005 patients were enrolled. Age was 59.3 ± 10.6 years, and 788 patients (78.4%) were men. Groups 1, 2, and 3 consisted of 613 (61.0%), 124 (12.3%), and 268 (26.7%) patients, respectively. HCC treatment included resection in 202 patients (20.1%), radiofrequency ablation ± transarterial chemoembolization in 311 patients (30.9%), and transarterial chemoembolization in 492 patients (49.0%). The median survival time differed significantly according to tumor stage (75.2, 44.9, and 30.3 months in groups 1, 2, and 3, respectively; P < 0.001). Multivariate analysis showed that group 2 had significantly worse survival compared with group 1 and similar survival to group 3. Conclusions: Patients in group 2 had a worse prognosis than those in group 1 and a similar prognosis to those in group 3. Our results suggest that BCLC stage B is the best stage designation for SLHCC. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | BCLC stage B is a better designation for single large hepatocellular carcinoma than BCLC stage A | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/jgh.13152 | - |
dc.identifier.scopusid | 2-s2.0-84955563054 | - |
dc.identifier.wosid | 000369398400028 | - |
dc.identifier.bibliographicCitation | Journal of Gastroenterology and Hepatology, v.31, no.2, pp 467 - 474 | - |
dc.citation.title | Journal of Gastroenterology and Hepatology | - |
dc.citation.volume | 31 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 467 | - |
dc.citation.endPage | 474 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION | - |
dc.subject.keywordPlus | TERTIARY REFERRAL CENTERS | - |
dc.subject.keywordPlus | LIVER-TRANSPLANTATION | - |
dc.subject.keywordPlus | HEPATIC RESECTION | - |
dc.subject.keywordPlus | EASL/AASLD RECOMMENDATIONS | - |
dc.subject.keywordPlus | TRANSARTERIAL CHEMOEMBOLIZATION | - |
dc.subject.keywordPlus | RADIOFREQUENCY ABLATION | - |
dc.subject.keywordPlus | SELECTION CRITERIA | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordAuthor | BCLC staging system | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | single large hepatocellular carcinoma | - |
dc.subject.keywordAuthor | treatment option | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.