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Cited 20 time in webofscience Cited 21 time in scopus
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The antibacterial effect of fatty acids on Helicobacter pylori infection

Authors
Jung, Sung WooLee, Sang Woo
Issue Date
Jan-2016
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Keywords
Helicobacter pylori; Fatty acids; Anti-bacterial agents; Liposomes; Drug delivery systems
Citation
KOREAN JOURNAL OF INTERNAL MEDICINE, v.31, no.1, pp.30 - 35
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
Volume
31
Number
1
Start Page
30
End Page
35
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6873
DOI
10.3904/kjim.2016.31.1.30
ISSN
1226-3303
Abstract
Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have decreased. Therefore, alternative treatments should be considered. The antibacterial properties of fatty acids (FAs) have been investigated in various organisms, including H. pylori. Some FAs, particularly polyunsaturated FAs, have been shown to have bactericidal activity against H. pylori in vitro; however, their antibacterial effects in vivo remain controversial. Poor solubility and delivery of FAs may be important reasons for this discrepancy. Recently, a series of studies demonstrated the antibacterial effects of a liposomal formulation of linolenic acid against H. pylori, both in vitro and in vivo. Further research is needed to improve the bioavailability of FAs and apply them in clinical use.
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Lee, Sang Woo
안산병원 (Department of Gastroenterology and Hepatology, Ansan Hospital)
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