The antibacterial effect of fatty acids on Helicobacter pylori infection
- Authors
- Jung, Sung Woo; Lee, Sang Woo
- Issue Date
- Jan-2016
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Helicobacter pylori; Fatty acids; Anti-bacterial agents; Liposomes; Drug delivery systems
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.31, no.1, pp 30 - 35
- Pages
- 6
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 31
- Number
- 1
- Start Page
- 30
- End Page
- 35
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6873
- DOI
- 10.3904/kjim.2016.31.1.30
- ISSN
- 1226-3303
2005-6648
- Abstract
- Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have decreased. Therefore, alternative treatments should be considered. The antibacterial properties of fatty acids (FAs) have been investigated in various organisms, including H. pylori. Some FAs, particularly polyunsaturated FAs, have been shown to have bactericidal activity against H. pylori in vitro; however, their antibacterial effects in vivo remain controversial. Poor solubility and delivery of FAs may be important reasons for this discrepancy. Recently, a series of studies demonstrated the antibacterial effects of a liposomal formulation of linolenic acid against H. pylori, both in vitro and in vivo. Further research is needed to improve the bioavailability of FAs and apply them in clinical use.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.