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만성 B형간염 환자에서 테노포비어 복용에 의한 판코니 증후군 발현 1예A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B
- Other Titles
- A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B
- Issue Date
- 2016
- Publisher
- 대한소화기학회
- Keywords
- Tenofovir; Hepatitis B virus; Fanconi syndrome; Kidney tubules; proximal; Osteomalacia
- Citation
- 대한소화기학회지, v.68, no.6, pp 317 - 320
- Pages
- 4
- Indexed
- SCOPUS
KCI
- Journal Title
- 대한소화기학회지
- Volume
- 68
- Number
- 6
- Start Page
- 317
- End Page
- 320
- ISSN
- 1598-9992
2233-6869
- Abstract
- Tenofovir disoproxil fumarate (TDF) is one of the most widely used treatment options for human immunodeficiency virus (HIV) and HBV infections. Despite its efficacy and safety, some cases of nephrotoxicity have been reported in the treatment of HIV patients. Even more recently, very few cases of Fanconi syndrome associated with tenofovir therapy in HBV monoinfection have been reported. Herein, we report a case of a 47-year-old male with an HBV monoinfection, who developed Fanconi syndrome and a secondary osteomalacia with multiple bone pain. After TDF withdrawal and supplementation of calcitriol, his renal function was reverted. Although the overall risk of TDF-associated nephrotoxicity is very low, both glomerular and tubular function should be monitored in patients undergoing TDF treatment.
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Related Researcher
- Jung, Young Kul
- Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)