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Gastric lesions in patients with Crohn's disease in Korea: A multicenter studyopen access

Authors
So H.Ye B.D.Park Y.S.Kim J.Kim J.S.Moon W.Lee K.-M.Kim Y.S.Keum B.Kim S.-E.Kim K.O.Kim E.S.Lee C.K.Hong S.P.Im J.P.Koo J.S.Choi C.H.Shin J.E.Lee B.I.Huh K.C.Kim Y.-H.Kim H.-S.Park Y.S.Han D.S.Korean Association for the Study of Intestinal Diseases
Issue Date
2016
Publisher
Korean Association for the Study of Intestinal Diseases
Keywords
Crohn disease; Gastritis; Granuloma; Helicobacter pylori; Stomach
Citation
Intestinal Research, v.14, no.1, pp.60 - 68
Indexed
SCOPUS
KCI
Journal Title
Intestinal Research
Volume
14
Number
1
Start Page
60
End Page
68
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7059
DOI
10.5217/ir.2016.14.1.60
ISSN
1598-9100
Abstract
Background/Aims: Gastric pathology and Helicobacter pylori (H. pylori ) infection among Asian patients with Crohn's disease (CD) are still unclear. We evaluated gastric histologic features and frequency of H. pylori infection in Korean patients with CD. Methods: Among 492 patients with CD receiving upper gastrointestinal (GI) endoscopic evaluation in 19 Korean hospitals, we evaluated the endoscopic findings and gastric histopathologic features of 47 patients for our study. Histopathologic classification was performed using gastric biopsy tissues, and H. pylori infection was determined using the rapid urease test and histology. Results: There were 36 men (76.6%), and the median age of patients at the time of upper GI endoscopy was 23.8 years (range, 14.2-60.5). For CD phenotype, ileocolonic disease was observed in 38 patients (80.9%), and non-stricturing, nonpenetrating disease in 31 patients (66.0%). Twenty-eight patients (59.6%) complained of upper GI symptoms. Erosive gastritis was the most common gross gastric feature (66.0%). Histopathologically, H. pylori -negative chronic active gastritis (38.3%) was the most frequent finding. H. pylori testing was positive in 11 patients (23.4%), and gastric noncaseating granulomata were detected in 4 patients (8.5%). Gastric noncaseating granuloma showed a statistically significant association with perianal abscess/ fistula (P =0.0496). Conclusions: H. pylori -negative chronic active gastritis appears to be frequent among Korean patients with CD. The frequency of H. pylori infection was comparable with previous studies. An association with perianal complications suggests a prognostic value for gastric noncaseating granuloma in patients with CD. © 2016. Korean Association for the Study of Intestinal Diseases. All rights reserved.
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Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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