Detailed Information

Cited 0 time in webofscience Cited 20 time in scopus
Metadata Downloads

Hepatitis B surface antigen titer is a good indicator of durable viral response after entecavir off-treatment for chronic hepatitis B

Authors
Lee, Han AhSeo, Yeon SeokPark, Seung WoonPark, Sang JungKim, Tae HyungSuh, Sang JunJung, Young KulKim, Ji HoonAn, HyongginYim, Hyung JoonYeon, Jong EunByun, Kwan SooUm, Soon Ho
Issue Date
Sep-2016
Publisher
Korean Association for the Study of the Liver
Keywords
Hepatitis B surface antigen; Hepatitis B virus; Off-treatment; Relapse
Citation
Clinical and Molecular Hepatology, v.22, no.3, pp 382 - 389
Pages
8
Indexed
SCOPUS
KCI
Journal Title
Clinical and Molecular Hepatology
Volume
22
Number
3
Start Page
382
End Page
389
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7089
DOI
10.3350/cmh.2016.0047
ISSN
2287-2728
2287-285X
Abstract
Background/Aims Clear indicators for stopping antiviral therapy in chronic hepatitis B (CHB) patients are not yet available. Since the level of hepatitis B surface antigen (HBsAg) is correlated with covalently closed circular DNA, the HBsAg titer might be a good indicator of the off-treatment response. This study aimed to determine the relationship between the HBsAg titer and the entecavir (ETV) off-treatment response. Methods This study analyzed 44 consecutive CHB patients (age, 44.6±11.4 years, mean±SD; men, 63.6%; positive hepatitis B envelope antigen (HBeAg) at baseline, 56.8%; HBV DNA level, 6.8±1.3 log10 IU/mL) treated with ETV for a sufficient duration and in whom treatment was discontinued after HBsAg levels were measured. A virological relapse was defined as an increase in serum HBV DNA level of >2000 IU/mL, and a clinical relapse was defined as a virological relapse with a biochemical flare, defined as an increase in the serum alanine aminotransferase level of >2 × upper limit of normal. Results After stopping ETV, virological relapse and clinical relapse were observed in 32 and 24 patients, respectively, during 20.8±19.9 months of follow-up. The cumulative incidence rates of virological relapse were 36.2% and 66.2%, respectively, at 6 and 12 months, and those of clinical relapse were 14.3% and 42.3%. The off-treatment HBsAg level was an independent factor associated with clinical relapse (hazard ratio, 2.251; 95% confidence interval, 1.076–4.706; P=0.031). When patients were grouped according to off-treatment HBsAg levels, clinical relapse did not occur in patients with an off-treatment HBsAg level of ≤2 log10 IU/mL (n=5), while the incidence rates of clinical relapse at 12 months after off-treatment were 28.4% and 55.7% in patients with off-treatment HBsAg levels of >2 and ≤3 log10 IU/mL (n=11) and >3 log10 IU/mL (n=28), respectively. Conclusion The off-treatment HBsAg level is closely related to clinical relapse after treatment cessation. A serum HBsAg level of <2 log10 IU/mL is an excellent predictor of a sustained off-treatment response in CHB patients who have received ETV for a sufficient duration.
Files in This Item
There are no files associated with this item.
Appears in
Collections
1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Ji Hoon photo

Kim, Ji Hoon
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE