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Improvement of liver function and non-invasive fibrosis markers in hepatitis B virus-associated cirrhosis: 2years of entecavir treatment

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dc.contributor.authorShin, Seung Kak-
dc.contributor.authorKim, Jeong Han-
dc.contributor.authorPark, Hyeonsu-
dc.contributor.authorKwon, Oh Sang-
dc.contributor.authorLee, Hyun Jung-
dc.contributor.authorYeon, Jong Eun-
dc.contributor.authorByun, Kwan Soo-
dc.contributor.authorSuh, Sang Jun-
dc.contributor.authorYim, Hyung Joon-
dc.contributor.authorKim, Yun Soo-
dc.contributor.authorKim, Ju Hyun-
dc.date.available2020-11-02T14:41:28Z-
dc.date.issued2015-12-
dc.identifier.issn0815-9319-
dc.identifier.issn1440-1746-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7281-
dc.description.abstractBackground and Aim Entecavir (ETV) induces biochemical and histologic improvement of the liver in patients with chronic hepatitis B. This study aimed to confirm that 2 years of ETV treatment improves liver function and non-invasive fibrosis markers in patients with hepatitis B virus (HBV)-associated cirrhosis. Methods A total 472 naïve patients with HBV-associated cirrhosis was treated with ETV for at least 2 years, between March 2007 and December 2012. Model for end-stage liver disease and Child-Pugh (CP) score were used to evaluate the improvement of liver function. Aspartate transaminase to platelet ratio index, FIB-4 index, and fibrosis index were used to evaluate the improvement of fibrosis. Results The final 370 of 472 patients with HBV-associated cirrhosis were enrolled. Mean age was 51 ± 10 years, and 240 patients (64.9%) were men. The distribution of CP class was 71.1% in A, 24.6% in B, and 4.3% in C. Mean end-stage liver disease and CP score changed over the study period from 8.5 ± 4.6 to 6.2 ± 4.2 (P < 0.001) and from 6.2 ± 1.6 to 5.6 ± 0.9 (P < 0.001), respectively. Aspartate transaminase to platelet ratio index, FIB-4 index, and fibrosis index changed from 3.6 ± 4.5 to 1.5 ± 1.5 (P < 0.001), from 7.0 ± 6.2 to 3.9 ± 2.8 (P < 0.001), and from 3.3 ± 0.9 to 2.5 ± 1.1 (P < 0.001), respectively. Conclusions After 2 years of treatment, ETV improves liver function and non-invasive fibrosis markers in patients with HBV-associated cirrhosis.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisherBlackwell Publishing Inc.-
dc.titleImprovement of liver function and non-invasive fibrosis markers in hepatitis B virus-associated cirrhosis: 2years of entecavir treatment-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1111/jgh.13020-
dc.identifier.scopusid2-s2.0-84954442333-
dc.identifier.wosid000367673200017-
dc.identifier.bibliographicCitationJournal of Gastroenterology and Hepatology, v.30, no.12, pp 1775 - 1781-
dc.citation.titleJournal of Gastroenterology and Hepatology-
dc.citation.volume30-
dc.citation.number12-
dc.citation.startPage1775-
dc.citation.endPage1781-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusDECOMPENSATED CIRRHOSIS-
dc.subject.keywordPlusLAMIVUDINE-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusINDEX-
dc.subject.keywordPlusBIOPSY-
dc.subject.keywordPlusREGRESSION-
dc.subject.keywordPlusADEFOVIR-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusPREDICT-
dc.subject.keywordAuthorentecavir-
dc.subject.keywordAuthorhepatitis B virus-
dc.subject.keywordAuthorliver fibrosis-
dc.subject.keywordAuthorliver function-
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Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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