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Cited 10 time in webofscience Cited 15 time in scopus
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Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Studyopen access

Authors
Shim, Ki-NamSong, Eun MiJeen, Yoon TaeKim, Jin-OhJeon, Seong RanChang, Dong KyungSong, Hyun JooLim, Yun JeongKim, Jin SooYe, Byong DukPark, Cheol HeeJeon, Seong WooCheon, Jae HeeLee, Kwang JaeKim, Ji HyunJang, Byung IkMoon, Jeong SeopChun, Hoon JaeChoi, Myung-Gyu
Issue Date
Nov-2015
Publisher
EDITORIAL OFFICE GUT & LIVER
Keywords
Anti-inflammatory agents; non-steroidal; Capsule endoscopy; Outcome
Citation
GUT AND LIVER, v.9, no.6, pp.727 - 733
Indexed
SCIE
SCOPUS
KCI
Journal Title
GUT AND LIVER
Volume
9
Number
6
Start Page
727
End Page
733
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7400
DOI
10.5009/gnl14134
ISSN
1976-2283
Abstract
Background/Aims: We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE). Methods: A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002. Results: A total of 140 patients (87 males; mean age, 60.6+/-14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0%) presented with a history of aspirin use and an additional 49 (35.0%) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%). During the follow-up period (mean, 15.9+/-19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3%). Older age and hypertension were positive predictive factors for recurrence. Conclusions: These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important.
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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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