Control of Mitochondrial Dynamics by Fas-induced Caspase-8 Activation in Hippocampal Neurons
- Authors
- Cho, Hyo Min; Sun, Woong
- Issue Date
- Sep-2015
- Publisher
- KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
- Keywords
- Fas; Mitochondrial dynamics; Hippocampal neurons; Apoptosis
- Citation
- EXPERIMENTAL NEUROBIOLOGY, v.24, no.3, pp 219 - 225
- Pages
- 7
- Indexed
- KCI
- Journal Title
- EXPERIMENTAL NEUROBIOLOGY
- Volume
- 24
- Number
- 3
- Start Page
- 219
- End Page
- 225
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7590
- DOI
- 10.5607/en.2015.24.3.219
- ISSN
- 1226-2560
2093-8144
- Abstract
- Cells undergo apoptosis mainly via two pathways-the mitochondrial pathway and the cytosolic pathway. It has been well documented that activation of the mitochondrial pathway promotes mitochondrial fragmentation and inhibition of mitochondrial fragmentation partly represses cell death. However, the mitochondrial events following activation of the cytosolic pathway are less understood. In this study, we treated Fas-activating antibody and found mitochondrial fragmentation without cell death in hippocampal primary neurons and HT-22 cell lines. Fas antibody treatment, in fact, promoted rapid activation of caspase-8, while executioner caspase-3 activation was not observed. Furthermore, blockage of caspase-8 efficiently prevented Fas antibody-induced mitochondrial fragmentation. These results suggest that the cytosolic pathway induced by death receptor activation promotes caspase-8-dependent mitochondrial fission.
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- Appears in
Collections - 1. Basic Science > Department of Anatomy > 1. Journal Articles
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