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Cited 35 time in webofscience Cited 34 time in scopus
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Usefulness of Core Needle Biopsy for Thyroid Nodules with Macrocalcifications: Comparison with Fine-Needle Aspiration

Authors
Yi, Kyung SikKim, Ji-hoonNa, Dong GyuSeo, HyobinMin, Hye SookWon, Jae-KyungYun, Tae JinRyoo, InseonKim, Su ChinChoi, Seung HongSohn, Chul-Ho
Issue Date
1-Jun-2015
Publisher
MARY ANN LIEBERT, INC
Citation
THYROID, v.25, no.6, pp 657 - 664
Pages
8
Indexed
SCI
SCIE
SCOPUS
Journal Title
THYROID
Volume
25
Number
6
Start Page
657
End Page
664
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7789
DOI
10.1089/thy.2014.0596
ISSN
1050-7256
1557-9077
Abstract
Background: This study was performed to determine the benefits of core needle biopsy (CNB), as compared with fine-needle aspiration (FNA), for the diagnosis of thyroid nodules with macrocalcifications. Materials and Methods: The institutional review board approved this retrospective study, and informed consent was waived. From February 2010 to March 2012, the study included 147 thyroid nodules with macrocalcification of 145 consecutive patients who underwent simultaneous FNA and CNB for each nodule. Diagnostic accuracy and inconclusive diagnoses, including nondiagnostic reading and atypia of undetermined significance or follicular lesion of undetermined significance reading were compared among FNA, CNB, and a combination of FNA and CNB (FNA/CNB) using McNemar's test; the benefits of CNB were calculated. Results: Compared to FNA, CNB and FNA/CNB showed fewer inconclusive diagnoses (FNA vs. CNB: 62/147 [42.2%] vs. 14/147 [9.5%], p<0.001; FNA vs. FNA/CNB: 62/147 [42.2%] vs. 14/147 [9.5%], p<0.001), resulting in the avoidance of repeat FNA or diagnostic surgery in 48 of 62 patients (77.4%, respectively in CNB and FNA/CNB) who would have undergone these procedures if only FNA was performed. Compared to FNA, FNA/CNB showed higher sensitivity and accuracy (sensitivity: 23/32 [71.9%] vs. 31/32 [96.9%], p=0.008; accuracy: 77/86 [89.5%] vs. 85/86 [98.8%], p=0.008), resulting in avoidance of delayed surgery in eight of nine patients (88.9%) with thyroid cancer in whom the surgery would have been missed if FNA only had been performed. Conclusion: In the workup of thyroid nodules with macrocalcification, compared with FNA alone, FNA/CNB decreases inconclusive diagnoses and increases sensitivity, thereby reducing repeated FNA procedures, diagnostic surgeries, and delayed therapeutic surgeries.
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Ryoo, Inseon
Guro Hospital (Department of Radiology, Guro Hospital)
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