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Cited 5 time in webofscience Cited 6 time in scopus
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Heat shock protein X purified from Mycobacterium tuberculosis enhances the efficacy of dendritic cells-based immunotherapy for the treatment of allergic asthmaopen access

Authors
Kim, Hye-youngKang, Hyun KyuCho, JoonJung, In DukYoon, Gun YoungLee, Min-GooShin, Sung JaePark, Won SunPark, Jong-HwanRyu, Seung-WookPark, Yeong-MinYou, Ji Chang
Issue Date
31-Mar-2015
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Keywords
Asthma; Dendritic cells; GATA-3; HspX; Mycobacterium tuberculosis; T-bet
Citation
BMB REPORTS, v.48, no.3, pp 178 - 183
Pages
6
Indexed
SCIE
SCOPUS
KCI
Journal Title
BMB REPORTS
Volume
48
Number
3
Start Page
178
End Page
183
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8051
DOI
10.5483/BMBRep.2015.48.3.257
ISSN
1976-6696
1976-670X
Abstract
Dendritic cells play an important role in determining whether naive T cells mature into either Th1 or Th2 cells. We determined whether heat-shock protein X (HspX) purified from Mycobacterium tuberculosis regulates the Th1/Th2 immune response in an ovalbumin (OVA)-induced murine model of asthma. HspX increased interferon-gamma, IL-17A, -12 and transforming growth factor (TGF)-beta production and T-bet gene expression but reduced IL-13 production and GATA-3 gene expression. HspX also inhibited asthmatic reactions as demonstrated by an increase in the number of eosinophils in bronchoalveolar lavage fluid, inflammatory cell infiltration in lung tissues, airway luminal narrowing, and airway hyper-responsiveness. Furthermore, HspX enhanced OVA-induced decrease of regulatory T cells in the mediastinal lymph nodes. This study provides evidence that HspX plays critical roles in the amelioration of asthmatic inflammation in mice. These findings provide new insights into the immunotherapeutic role of HspX with respect to its effects on a murine model of asthma.
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