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Cited 13 time in webofscience Cited 12 time in scopus
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1 alpha,25-Dihydroxyvitamin D-3 upregulates HIF-1 and TREM-1 via mTOR signaling

Authors
Lee, BitnaraKwon, EunjiKim, YongjinKim, Jin HeeSon, Sang WookLee, Jin KyuKim, Dong WonSohn, JeongwonKim, Tae-HwanJi, Jong Dae
Issue Date
Jan-2015
Publisher
Elsevier BV
Keywords
TREM-1; 1 alpha,25-dihydroxyviamin D-3; mTOR; Monocytes; Macrophages
Citation
Immunology Letters, v.163, no.1, pp 14 - 21
Pages
8
Indexed
SCI
SCIE
SCOPUS
Journal Title
Immunology Letters
Volume
163
Number
1
Start Page
14
End Page
21
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8273
DOI
10.1016/j.imlet.2014.11.004
ISSN
0165-2478
1879-0542
Abstract
Triggering receptor expressed on myeloid cells-1 (TREM-1) is induced by 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) in human monocytes/macrophages and epithelial cells. However, little information is available regarding the mechanism of 1,25(OH)(2)D-3-induced TREM-1 expression in human monocytes/macrophages. In this study, 1,25(OH)(2)D-3 was shown to strongly upregulate hypoxia-inducible transcription factor (HIF) in PMA-differentiated U937 cells. However, HIF was not mainly involved in 1,25(OH)(2)D-3-induced TREM-1 expression. Instead, 1,25(OH)(2)D-3-induced expression of TREM-1 was inhibited by rapamycin, a specific inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, indicating the involvement of mTOR. Induction of HIF proteins by 1,25(OH)(2)D-3 was also inhibited by rapamycin. In addition, 1,25(OH)(2)D-3 induced the phosphorylation of p70S6 kinase, a target of mTOR complex 1 (mTORC1). Our results suggest that 1,25(OH)(2)D-3 induces the expression of TREM-1 through the mTOR signaling pathway in human macrophages. (C) 2014 Elsevier B.V. All rights reserved.
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