Detailed Information

Cited 3 time in webofscience Cited 2 time in scopus
Metadata Downloads

ZNF804A Gene Variants Have a Cross-diagnostic Influence on Psychosis and Treatment Improvement in Mood Disorders

Authors
Calabro, MarcoMandelli, LauraCrisafulli, ConcettaDi Nicola, MarcoColombo, RobertoJaniri, LuigiLee, Soo-JungJun, Tae-YounWang, Sheng-MinMasand, Prakash S.Patkar, Ashwin A.Han, ChangsuPae, Chi-UnSerretti, Alessandro
Issue Date
May-2020
Publisher
대한정신약물학회
Keywords
ZNF804A; Bipolar disorder; Major depressive disorder; Symptoms improvement; Psychotic disorders
Citation
Clinical Psychopharmacology and Neuroscience, v.18, no.2, pp 231 - 240
Pages
10
Indexed
SCIE
SCOPUS
KCI
Journal Title
Clinical Psychopharmacology and Neuroscience
Volume
18
Number
2
Start Page
231
End Page
240
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/835
DOI
10.9758/cpn.2020.18.2.231
ISSN
1738-1088
2093-4327
Abstract
Objective: Genetic variations in the gene encoding zinc finger protein 804A gene (ZNF804A) have been associated with major depression and bipolar disorder. In this work we focused on the potential influence of ZNF804A variations on the risk of developing specific sub-phenotypes as well as the individual response to available treatments. Methods: We used two samples of different ethnic origin: a Korean sample, composed by 242 patients diagnosed with major depression and 132 patients diagnosed with bipolar disorder and 326 healthy controls; an Italian sample composed 151 major depression subjects, 189 bipolar disorder subjects and 38 outpatients diagnosed for a primary anxiety disorder. Results: Our analyses reported an association of rs1344706 with psychotic phenotype in the cross-diagnostic pooled sample (geno p = 4.15 × 10−4, allelic p = 1.06 × 10−4). In the cross-diagnosis Italian sample but not in the Korean one, rs7597593 was involved with depressive symptoms improvement after treatment (geno p = 0.025, allelic p = 0.007). Conclusion: The present study evidenced the role of ZNF804A alterations in symptoms improvement after treatment. Both manic and depressive symptoms seem to be modulated by ZNF804A, though the latter was observed in the bipolar pooled sample only. The role of this factor is likely related to synaptic development and maintenance; however, further analyses will be needed to better understand the molecular mechanics involved with ZNF804A.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Psychiatry > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Han, Changsu photo

Han, Changsu
Ansan Hospital (Department of Psychiatry, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE