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Prevalence, risk factors and clinical characteristics in patients with genotype 6 chronic hepatitis C: a single institute experience

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dc.contributor.authorShin S.K.-
dc.contributor.authorPark S.Y.-
dc.contributor.authorJung Y.K.-
dc.contributor.authorKim E.J.-
dc.contributor.authorLee H.N.-
dc.contributor.authorLee J.J.-
dc.contributor.authorKwon O.S.-
dc.contributor.authorChoi D.J.-
dc.contributor.authorKim Y.S.-
dc.contributor.authorKim J.H.-
dc.date.available2020-11-02T16:42:50Z-
dc.date.issued2015-
dc.identifier.issn1598-9992-
dc.identifier.issn2233-6869-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8392-
dc.description.abstractBACKGROUND/AIMS: Hepatitis C genotypes 1 and 2 are widely distributed globally. In contrast, genotype 6 is found mainly in Southeast Asia, while genotype 6 is rare in Korea. This study aims to investigate the prevalence, risk factors and clinical characteristics of patients with genotype 6 chronic hepatitis C.METHODS: We retrospectively identified 133 HCV-infected patients who underwent HCV genotype analysis between January 2012 and December 2012, and analyzed the prevalence, risk factors and clinical characteristics of patients diagnosed with genotype 6 chronic hepatitis C.RESULTS: Among 133 patients, 53 patients (39.8%) were infected with genotype 1, 62 patients (46.6%) with genotype 2, 2 patients (1.5%) with genotype 3, 14 patients (10.5%) with genotype 6, and 2 patients (1.5%) with mixed genotypes (genotype 1 and 6). The risk factors associated with genotype 6 were acupuncture (n=4, 28.6%), intravenous drug use (n=3, 21.4%), tattoo (n=2, 14.3%), and transfusion (n=2, 14.3%). Of the 14 patients with genotype 6, 6 patients were treated with pegylated interferon and ribavirin. Five patients had reached the end of treatment. All patients reaching end of treatment for genotype 6 showed early virological response and sustained virological response.CONCLUSIONS: The prevalence of genotype 6 is 10.5% and mixed infections of genotype 1 and 6 are 1.5% in patients with chronic hepatitis C. A major potential risk factor is intravenous drug use and the treatment response rate to pegylated interferon plus ribavirin is high in patients with genotype 6 chronic hepatitis C. Large scale multicenter studies are needed.-
dc.format.extent7-
dc.language한국어-
dc.language.isoKOR-
dc.titlePrevalence, risk factors and clinical characteristics in patients with genotype 6 chronic hepatitis C: a single institute experience-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.4166/kjg.2015.65.2.105-
dc.identifier.scopusid2-s2.0-85015354646-
dc.identifier.bibliographicCitationThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.65, no.2, pp 105 - 111-
dc.citation.titleThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi-
dc.citation.volume65-
dc.citation.number2-
dc.citation.startPage105-
dc.citation.endPage111-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.subject.keywordPlusalpha interferon-
dc.subject.keywordPlusantivirus agent-
dc.subject.keywordPlusmacrogol derivative-
dc.subject.keywordPluspeginterferon alpha2a-
dc.subject.keywordPlusrecombinant protein-
dc.subject.keywordPlusribavirin-
dc.subject.keywordPlusvirus RNA-
dc.subject.keywordPlusacupuncture-
dc.subject.keywordPlusadult-
dc.subject.keywordPlusaged-
dc.subject.keywordPlusblood transfusion-
dc.subject.keywordPluscombination drug therapy-
dc.subject.keywordPlusfemale-
dc.subject.keywordPlusgenetics-
dc.subject.keywordPlusgenotype-
dc.subject.keywordPlusHepacivirus-
dc.subject.keywordPlusHepatitis C, Chronic-
dc.subject.keywordPlushuman-
dc.subject.keywordPlusisolation and purification-
dc.subject.keywordPlusmale-
dc.subject.keywordPlusmiddle aged-
dc.subject.keywordPlusprevalence-
dc.subject.keywordPlusretrospective study-
dc.subject.keywordPlusrisk factor-
dc.subject.keywordPlusSouth Korea-
dc.subject.keywordPlustattooing-
dc.subject.keywordPlusAcupuncture Therapy-
dc.subject.keywordPlusAdult-
dc.subject.keywordPlusAged-
dc.subject.keywordPlusAntiviral Agents-
dc.subject.keywordPlusBlood Transfusion-
dc.subject.keywordPlusDrug Therapy, Combination-
dc.subject.keywordPlusFemale-
dc.subject.keywordPlusGenotype-
dc.subject.keywordPlusHepacivirus-
dc.subject.keywordPlusHepatitis C, Chronic-
dc.subject.keywordPlusHumans-
dc.subject.keywordPlusInterferon-alpha-
dc.subject.keywordPlusMale-
dc.subject.keywordPlusMiddle Aged-
dc.subject.keywordPlusPolyethylene Glycols-
dc.subject.keywordPlusPrevalence-
dc.subject.keywordPlusRecombinant Proteins-
dc.subject.keywordPlusRepublic of Korea-
dc.subject.keywordPlusRetrospective Studies-
dc.subject.keywordPlusRibavirin-
dc.subject.keywordPlusRisk Factors-
dc.subject.keywordPlusRNA, Viral-
dc.subject.keywordPlusTattooing-
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Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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