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Evaluation of the microenvironmental heterogeneity in high-grade gliomas with IDH1/2 gene mutation using histogram analysis of diffusion-weighted imaging and dynamic-susceptibility contrast perfusion imaging

Authors
Lee S.Choi S.H.Ryoo I.Yoon T.J.Kim T.M.Lee S.-H.Park C.-K.Kim J.-H.Sohn C.-H.Park S.-H.Kim I.H.
Issue Date
2015
Publisher
Springer New York LLC
Keywords
ADC; DSC-PWI; DWI; High-grade gliomas; IDH gene mutation; Isocitrate dehydrogenase; nCBV
Citation
Journal of Neuro-Oncology, v.121, no.1, pp 141 - 150
Pages
10
Indexed
SCI
SCIE
SCOPUS
Journal Title
Journal of Neuro-Oncology
Volume
121
Number
1
Start Page
141
End Page
150
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8529
DOI
10.1007/s11060-014-1614-z
ISSN
0167-594X
1573-7373
Abstract
The purpose of our study was to explore the difference between isocitrate dehydrogenase (IDH)-1/2 gene mutation-positive and -negative high-grade gliomas (HGGs) using histogram analysis of apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps. We enrolled 52 patients with histopathologically confirmed HGGs with IDH1/2P (n = 16) or IDH1/2N (n = 36). Histogram parameters of ADC and nCBV maps were correlated with gene mutations by using the unpaired student’s t test and multivariable stepwise logistic regression analysis. The mean ADC value was higher in the IDH1P group than IDH1N (1,282.8 vs. 1,159.6 mm2/s, P = .0113). In terms of the cumulative ADC histograms, the 10th and 50th percentile values were also higher in the IDH1P than IDH1N (P = .0104 and.0183, respectively). We observed a higher 90th percentile value (3.121 vs. 2.397, P = .0208) and a steeper slope between the 10th (C10) and 90th (C90) of cumulative nCBV histograms (0.03386 vs. 0.02425/%, P = .0067) in the IDH1N group. Multivariate analysis showed that the mean ADC mean value (P = .0048), the C90 value (P = .0113), and the slope between C10 and C90 (P = .0049) were the significant variables in the differentiation of IDH1P from IDH1N. In conclusion, histogram analysis of ADC and nCBV maps based on entire tumor volume can be a useful tool for distinguishing IDH1P and IDH1N, and it predicts that IDHP tumors have a more heterogeneous microenvironment than IDHN ones. © 2014, Springer Science+Business Media New York.
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