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Cited 19 time in webofscience Cited 22 time in scopus
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Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia

Authors
Jung, Jin-SookLee, Heon-JeongCho, Chul-HyunKang, Seung-GulYoon, Ho-KyoungPark, Young-MinMoon, Joung-HoYang, Hee-JungSong, Hyun-MiKim, Leen
Issue Date
Aug-2014
Publisher
TAYLOR & FRANCIS INC
Keywords
Antipsychotics; circadian rhythm; CLOCK gene; restless legs syndrome
Citation
CHRONOBIOLOGY INTERNATIONAL, v.31, no.7, pp 838 - 844
Pages
7
Indexed
SCI
SCIE
SCOPUS
Journal Title
CHRONOBIOLOGY INTERNATIONAL
Volume
31
Number
7
Start Page
838
End Page
844
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9097
DOI
10.3109/07420528.2014.914034
ISSN
0742-0528
1525-6073
Abstract
Previous studies have suggested that there is a genetic basis to restless legs syndrome (RLS) development. Occurrence of antipsychotic-induced RLS could also be due to differences in genetic susceptibility. We investigated whether CLOCK and NPAS2 gene polymorphisms are associated with RLS in schizophrenic patients on antipsychotics because RLS symptoms usually manifest during the evening and night. We assessed symptoms of RLS in 190 Korean schizophrenic patients on antipsychotics and divided the subjects into two groups according to the International Restless Legs Syndrome Study Group diagnostic criteria: (i) subjects who met all the criteria and (ii) the remaining subjects who did not meet all the criteria. We found a significant difference in the number of subjects with different genotype and allele carrier frequencies for the CLOCK gene (rs2412646) between the two groups (p = 0.031 and 0.010, respectively). Distribution of CLOCK haplotypes (rs2412646-rs1801260) was significantly different between schizophrenic patients with and without RLS (p = 0.021). However, the distributions of allelic, genotypic, and haplotypic variants of NPAS2 (rs2305160 and rs6725296) were not significantly different between the two groups. Our results suggest that CLOCK polymorphisms are associated with increased susceptibility of schizophrenic patients to RLS. We hypothesize that RLS in schizophrenia patients treated with antipsychotics may be a very mild akathisia that manifests during the night and is under control of circadian oscillation.
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Lee, Heon Jeong
Anam Hospital (Department of Psychiatry, Anam Hospital)
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