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Cited 11 time in webofscience Cited 11 time in scopus
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Multiparametric MR Is a Valuable Modality for Evaluating Disease Severity of Nonalcoholic Fatty Liver Diseaseopen access

Authors
Lee, Young-SunYoo, Yang JaeJung, Young KulKim, Ji HoonSeo, Yeon SeokYim, Hyung JoonKim, In HeeLee, Soo YeonKim, Baek HuiKim, Jeong WooLee, Chang HeeYeon, Jong EunKwon, So YoungUm, Soon HoByun, Kwan Soo
Issue Date
Apr-2020
Publisher
Nature Publishing Group
Citation
Clinical and Translational Gastroenterology, v.11, no.4
Indexed
SCIE
SCOPUS
Journal Title
Clinical and Translational Gastroenterology
Volume
11
Number
4
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/917
DOI
10.14309/ctg.0000000000000157
Abstract
INTRODUCTION: Because nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of chronic liver disease, noninvasive evaluations of its severity are immediately needed. This prospective cross-sectional study evaluated the effectiveness of noninvasive assessments of hepatic steatosis, fibrosis, and steatohepatitis. METHODS: Patients underwent laboratory tests, liver biopsy, transient elastography, and MRI. Multiparametric MR was used to measure MRI proton density fat fraction, MR spectroscopy, T1 mapping, and MR elastography (MRE). RESULTS: We enrolled 130 patients between October 2016 and July 2019. For the diagnosis of moderate-to-severe steatosis (grade ≥ 2), the area under the receiver operating characteristic curve (AUROC) was lower in controlled attenuation parameter (0.69; 95% confidence interval [CI], 0.60–0.76) than MRI proton density fat fraction (0.82; 95% CI, 0.75–0.89; P = 0.008) and MR spectroscopy (0.83; 95% CI, 0.75–0.89; P = 0.006). For the diagnosis of advanced fibrosis (stage ≥ 3), the AUROC of MRE (0.89; 95% CI, 0.83–0.94) was superior compared with those of the Fibrosis-4 index (0.77; 95% CI, 0.69–0.84; P = 0.010), NAFLD fibrosis score (0.81; 95% CI, 0.73–0.87; P = 0.043), and transient elastography (0.82; 95% CI, 0.74–0.88; P = 0.062). For detecting advanced fibrosis or nonalcoholic steatohepatitis, the AUROC of MRE (0.86; 95% CI, 0.79–0.91) was higher than that of TE (0.76; 95% CI, 0.68–0.83) with statistical significance (P = 0.018). DISCUSSION: Multiparametric MR accurately identified a severe form of NAFLD. Multiparametric MR can be a valuable noninvasive method for evaluating the severity of NAFLD.
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2. Clinical Science > Department of Pathology > 1. Journal Articles
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Kim, Ji Hoon
구로병원 (Department of Gastroenterology and Hepatology, Guro Hospital)
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