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Cited 35 time in webofscience Cited 38 time in scopus
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Using intravoxel incoherent motion (IVIM) MR imaging to predict lipiodol uptake in patients with hepatocellular carcinoma following transcatheter arterial chemoembolization: A preliminary result

Authors
Park, Yang ShinLee, Chang HeeKim, Ji HoonKim, In SeongKiefer, BertholdSeo, Tae SeokKim, Kyeong AhPark, Cheol Min
Issue Date
Jul-2014
Publisher
ELSEVIER SCIENCE INC
Keywords
Liver; MRI; IVIM; DWI; TACE; Hepatocellular carcinoma
Citation
MAGNETIC RESONANCE IMAGING, v.32, no.6, pp 638 - 646
Pages
9
Indexed
SCI
SCIE
SCOPUS
Journal Title
MAGNETIC RESONANCE IMAGING
Volume
32
Number
6
Start Page
638
End Page
646
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9180
DOI
10.1016/j.mri.2014.03.003
ISSN
0730-725X
1873-5894
Abstract
Purpose: To assess the usefulness of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) for predicting lipiodol uptake in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Materials and methods: The institutional review board approved this study. 44 HCC patients underwent IVIM-DWI and Gd-EOB-DTPA-enhanced MRI prior to TACE. Using post-TACE CT as a reference standard, each HCC was classified into either lipiodol good uptake (LGU) or poor uptake (LPU) group. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion coefficient (D*), and perfusion fraction (f) in HCC were calculated. Arterial enhancement ratio (AER) and IVIM parameters were compared between those two groups using the Mann-Whitney U test. Results: Of the 51 HCCs, 37 (72.5%) were LGU group and 14 (27.5%) were LPU group. AER of HCC was significantly higher in LGU than LPU (0.99 +/- 0.54 and 0.67 +/- 0.45; P = .034). ADC, D, and f values were not significantly different (P = .073, .059, and .196, respectively) between these two groups. D* was significantly elevated in LGU than LPU (48.10 +/- 15.33 and 26.75 +/- 9.55; P = .001). Conclusion: Both AER derived from contrast enhanced MRI and D* values derived from IVIM-DWI for HCC were significantly higher in LGU than in LPU. These parameters would be helpful for predicting the lipiodol uptake. (C) 2014 Elsevier Inc. All rights reserved.
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Kim, Ji Hoon
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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