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Cited 16 time in webofscience Cited 15 time in scopus
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The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Canceropen access

Authors
Bae, Hyo SookHong, Jin HwaKi, Kyoung-DoSong, Jae YunShin, Jin WooLee, Jong MinLee, Jae KwanLee, Nak WooLee, ChanLee, Kyu WanKim, Yong Min
Issue Date
Jun-2014
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Ovarian Neoplasms; Survival; Body Mass Index; Obesity
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.6, pp 793 - 797
Pages
5
Indexed
SCI
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
29
Number
6
Start Page
793
End Page
797
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9255
DOI
10.3346/jkms.2014.29.6.793
ISSN
1011-8934
1598-6357
Abstract
Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P = 0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients.
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Hong, Jin Hwa
Guro Hospital (Department of Obstetrics and Gynecology, Guro Hospital)
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