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Cited 37 time in webofscience Cited 44 time in scopus
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Chemotherapy- induced Focal Hepatopathy in Patients with Gastrointestinal Malignancy: Gadoxetic Acid-enhanced and Diffusion-weighted MR Imaging with Clinical-Pathologic Correlation

Authors
Han, Na YeonPark, Beom JinSung, Deuk JaeKim, Min JuCho, Sung BumLee, Chang HeeJang, Yun-JinKim, So YeonKim, Dong SikUm, Soon HoWon, Nam HeeYang, Kyung Sook
Issue Date
May-2014
Publisher
RADIOLOGICAL SOC NORTH AMERICA
Citation
RADIOLOGY, v.271, no.2, pp 416 - 425
Pages
10
Indexed
SCI
SCIE
SCOPUS
Journal Title
RADIOLOGY
Volume
271
Number
2
Start Page
416
End Page
425
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9324
DOI
10.1148/radiol.13131810
ISSN
0033-8419
1527-1315
Abstract
Purpose: To retrospectively evaluate findings of chemotherapy-induced focal hepatopathy (CIFH) on gadoxetic acidenhanced magnetic resonance (MR) and diffusion-weighted (DW) images and to determine imaging features that are most helpful in differentiating CIFH from metastasis. Materials and Methods: This retrospective study was approved by the institutional review board, and informed consent was waived. MR images, including DW images and gadoxetic acid-enhanced images, from 12 patients (four men, eight women; age range, 25-64 years) with 15 CIFHs were reviewed independently and in consensus by two radiologists and were compared with those obtained in 20 control patients (12 men, eight women; age range, 32-84 years) with 30 hepatic metastasis who were matched for tumor size, primary organ, and chemotherapy regimen. Interobserver agreement was assessed with kappa statistics, and univariate analysis was performed for comparisons. For quantitative analyses, apparent diffusion coefficients (ADCs) and lesion-to-liver contrast ratios (CRs) were measured. Histopathologic examinations were performed for CIFHs. Results: Histopathologic examination revealed that the development of CIFHs was attributable to accentuated manifestations of sinusoidal obstruction syndrome. Interobserver agreement was excellent (kappa > 0.85). An ill-defined margin on hepatobiliary phase (HBP) images was the most discriminating independent variable in the differentiation of CIFH from metastasis (odds ratio, 16; P =.009). ADC and CR values in CIFH group were significantly higher than those in metastasis group (P <.001 and P =.041). Conclusion: CIFH should be considered a mimicker of metastasis in patients with gastrointestinal malignancy during chemotherapy. CIFH can be differentiated from metastasis on the basis of gadoxetic acid-enhanced MR and DW imaging findings; an ill-defined margin on HBP images was especially characteristic. (C) RSNA, 2014
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1. Basic Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
2. Clinical Science > Department of Hepato-Biliary-Pancreatic Surgery > 1. Journal Articles
2. Clinical Science > Department of Radiology > 1. Journal Articles

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Sung, Deuk Jae
Anam Hospital (Department of Radiology, Anam Hospital)
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