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Cited 12 time in webofscience Cited 14 time in scopus
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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Authors
Wong, Jason Y. Y.Zhang, HanHsiung, Chao A.Shiraishi, KouyaYu, KaiMatsuo, KeitaroWong, Maria PikHong, Yun-ChulWang, JiucunSeow, Wei JieWang, ZhaomingSong, MinsunKim, Hee NamChang, I-ShouChatterjee, NilanjanHu, WeiWu, ChenMitsudomi, TetsuyaZheng, WeiKim, Jin HeeSeow, AdelineCaporaso, Neil E.Shin, Min-HoChung, Lap PingAn, She-JuanWang, PingYang, YangZheng, HongYatabe, YasushiZhang, Xu-ChaoKim, Young TaeCai, QiuyinYin, ZhihuaKim, Young-ChulBassig, Bryan A.Chang, JiangHo, James Chung N.Ji, Bu-TianDaigo, YataroIto, HidemiMomozawa, YukihideAshikawa, KyotaKamatani, YoichiroHonda, TakayukiHosgood, H. DeanSakamoto, HiromiKunitoh, HideoTsuta, KojiWatanabe, Shun-IchiKubo, MichiakiMiyagi, YoheiNakayama, HaruhikoMatsumoto, ShingoTsuboi, MasahiroGoto, KoichiShi, JianxinSong, LeiHua, XingTakahashi, AtsushiGoto, AkiteruMinamiya, YoshihiroShimizu, KimihiroTanaka, KazumiWei, FushengMatsuda, FumihikoSu, JianKim, Yeul HongOh, In-JaeSong, FengjuSu, Wu-ChouChen, Yu-MinChang, Gee-ChenChen, Kuan-YuHuang, Ming-ShyanChien, Li-HsinXiang, Yong-BingPark, Jae YongKweon, Sun-SeogChen, Chien-JenLee, Kyoung-MuBlechter, BatelLi, HaixinGao, Yu-TangQian, BiyunLu, DaruLiu, JianjunJeon, Hyo-SungHsiao, Chin-FuSung, Jae SookTsai, Ying-HuangJung, Yoo JinGuo, HuanHu, ZhibinWang, Wen-ChangChung, Charles C.Burdett, LaurieYeager, MeredithHutchinson, AmyBerndt, Sonja, IWu, WeiPang, HerbertLi, YuqingChoi, Jin EunPark, Kyong HwaSung, Sook WhanLiu, LiKang, C. H.Zhu, MengChen, Chung-HsingYang, Tsung-YingXu, JunGuan, PengTan, WenWang, Chih-LiangHsin, MichaelSit, Ko-YungHo, JamesChen, YingChoi, Yi YoungHung, Jen-YuKim, Jun SukYoon, Ho IlLin, Chien-ChungPark, In KyuXu, PingWang, YuzhuoHe, QinchengPerng, Reury-PerngChen, Chih-YiVermeulen, RoelWu, JunjieLim, Wei-YenChen, Kun-ChiehLi, Yao-JenLi, JihuaChen, HongyanYu, Chong-JenJin, LiChen, Tzu-YuJiang, Shih-ShengLiu, JieYamaji, TaikiHicks, BelyndaWyatt, KathleenLi, Shengchao A.Dai, JunchengMa, HongxiaJin, GuangfuSong, BaoWang, ZhehaiCheng, SensenLi, XuelianRen, YangwuCui, PingIwasaki, MotokiShimazu, TaichiTsugane, ShoichiroZhu, JunjieYang, KaiyunJiang, GeningFei, KeWu, GuopingLin, Hsien-ChinChen, Hui-LingFang, Yao-HueiTsai, Fang-YuHsieh, Wan-ShanYu, JinmingStevens, Victoria L.Laird-Offringa, Ite A.Marconett, Crystal N.Rieswijk, LindaChao, AnnYang, Pan-ChyrShu, Xiao-OuWu, TangchunWu, Y. L.Lin, DongxinChen, KexinZhou, BaosenHuang, Yun-ChaoKohno, TakashiShen, HongbingChanock, Stephen J.Rothman, NathanielLan, Qing
Issue Date
Mar-2020
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Tuberculosis; Lung cancer; Lung adenocarcinoma; Mendelian randomization; Pathway analysis
Citation
Genomics, v.112, no.2, pp 1223 - 1232
Pages
10
Indexed
SCIE
SCOPUS
Journal Title
Genomics
Volume
112
Number
2
Start Page
1223
End Page
1232
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/945
DOI
10.1016/j.ygeno.2019.07.008
ISSN
0888-7543
1089-8646
Abstract
We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
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Park, Kyong Hwa
Anam Hospital (Department of Medical Oncology and Hematology, Anam Hospital)
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