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Relationship between the Severity of Diversion Colitis and the Composition of Colonic Bacteria: A Prospective Study

Authors
Baek, Se-JinKim, Seon-HahnLee, Chang-KyuRoh, Kyoung-HoKeum, BoraKim, Chul-HwanKim, Jin
Issue Date
Mar-2014
Publisher
EDITORIAL OFFICE GUT & LIVER
Keywords
Diversion colitis; Colonic bacteria; Rectal neo-plasms; Polymerase chain reaction
Citation
GUT AND LIVER, v.8, no.2, pp 170 - 176
Pages
7
Indexed
SCIE
SCOPUS
KCI
Journal Title
GUT AND LIVER
Volume
8
Number
2
Start Page
170
End Page
176
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9544
DOI
10.5009/gnl.2014.8.2.170
ISSN
1976-2283
2005-1212
Abstract
Background/Aims: Diversion colitis is the inflammation of the excluded segment of the colon in patients undergoing ostomy. It has been suggested that a change in colonic flora may lead to colitis; however, direct evidence for this disease progression is lacking. The aim of this study was to evaluate the relationship between the severity of diversion colitis and the composition of colonic bacteria. Methsods: We used culture methods and polymerase chain reaction to analyze the colonic microflora of patients who underwent rectal cancer resection with or without diversion ileostomy. In the diversion group, we also evaluated the severity of colonoscopic and pathologic colitis before reversal. Results: This study enrolled 48 patients: 26 in the diversion group and 22 in the control group. Significant differences were observed between the two groups in the levels of Staphylococcus (p=0.038), Enterococcus (p<0.001), Klebsiella (p<0.001), Pseudomonas (p=0.015), Lactobacillus (p=0.038), presence of anaerobes (p=0.019), and Bifidobacterium (p<0.001). A. significant correlation between the severity of colitis and bacterial composition was only observed for Bifidobacterium (p=0.005, correlation coefficient=-0.531). Conclusions: The colonic microflora differed significantly between the diversion and control groups. Bifidobacterium was negatively correlated with the severity of diversion colitis.
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2. Clinical Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles

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Baek, Se Jin
Anam Hospital (Department of Colon and Rectal Surgery, Anam Hospital)
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