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Clinical Characteristics and Outcomes of Acute Hepatitis A in Korea: A Nationwide Multicenter Study

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dc.contributor.authorKwon, So Young-
dc.contributor.authorPark, Sang Hoon-
dc.contributor.authorYeon, Jong Eun-
dc.contributor.authorJeong, Sook Hyang-
dc.contributor.authorKwon, Oh Sang-
dc.contributor.authorLee, Jin Woo-
dc.contributor.authorKim, Hong Soo-
dc.contributor.authorSeo, Yeon Seok-
dc.contributor.authorKim, Young Seok-
dc.contributor.authorSohn, Joo Hyun-
dc.contributor.authorYim, Hyung Joon-
dc.contributor.authorChoi, Jong Young-
dc.contributor.authorLee, Myung Seok-
dc.contributor.authorKweon, Young Oh-
dc.contributor.authorCheong, Jae Youn-
dc.contributor.authorKim, Haak Cheoul-
dc.contributor.authorLee, Heon Ju-
dc.contributor.authorBaik, Soon Koo-
dc.contributor.authorAn, Hyonggin-
dc.contributor.authorByun, Kwan Soo-
dc.date.available2020-11-02T18:46:26Z-
dc.date.issued2014-02-
dc.identifier.issn1011-8934-
dc.identifier.issn1598-6357-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9605-
dc.description.abstractThe aim of this study was to investigate the clinical characteristics of acute hepatitis A during a recent outbreak in Korea. Data of patients diagnosed with acute hepatitis A from 2007 to 2009 were collected from 21 tertiary hospitals retrospectively. Their demographic, clinical, and serological characteristics and their clinical outcomes were analyzed. A total of 4,218 patients (mean age 33.3 yr) were included. The median duration of admission was 9 days. The mean of the highest ALT level was 2,963 IU/L, total bilirubin was 7.3 mg/dL, prothrombin time INR was 1.3. HBsAg was positive in 3.7%, and anti-HCV positive in 0.7%. Renal insufficiency occurred in 2.7%, hepatic failure in 0.9%, relapsing hepatitis in 0.7%, and cholestatic hepatitis in 1.9% of the patients. Nineteen patients (0.45%) died or were transplanted. Complications of renal failure or prolonged cholestasis were more frequent in patients older than 30 yr. In conclusion, most patients with acute hepatitis A recover uneventfully, however, complication rates are higher in patients older than 30 yr than younger patients. Preventive strategies including universal vaccination in infants and active immunization of hepatitis A to adult population should be considered for prevention of community-wide outbreaks of hepatitis A in Korea.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisher대한의학회-
dc.titleClinical Characteristics and Outcomes of Acute Hepatitis A in Korea: A Nationwide Multicenter Study-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.3346/jkms.2014.29.2.248-
dc.identifier.scopusid2-s2.0-84907669521-
dc.identifier.wosid000333154700015-
dc.identifier.bibliographicCitationJournal of Korean Medical Science, v.29, no.2, pp 248 - 253-
dc.citation.titleJournal of Korean Medical Science-
dc.citation.volume29-
dc.citation.number2-
dc.citation.startPage248-
dc.citation.endPage253-
dc.type.docTypeArticle-
dc.identifier.kciidART001849082-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPlusLIVER-DISEASE-
dc.subject.keywordPlusVIRUS-
dc.subject.keywordPlusFAILURE-
dc.subject.keywordPlusMANIFESTATIONS-
dc.subject.keywordPlusEPIDEMIOLOGY-
dc.subject.keywordPlusVACCINATION-
dc.subject.keywordPlusETIOLOGY-
dc.subject.keywordPlusFEATURES-
dc.subject.keywordAuthorHepatitis A-
dc.subject.keywordAuthorMorbidity-
dc.subject.keywordAuthorMortality-
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1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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