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Cited 19 time in webofscience Cited 23 time in scopus
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High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Authors
Ko, Sun-YoungPark, Chan-JeoungPark, Sang-HyukCho, Young-UkJang, SeongsooSeo, Eul-juKim, NayoungKim, Dae-YoungKoh, Kyung NamIm, Ho JoonSeo, Jong-JinChi, Hyun-Sook
Issue Date
Jan-2014
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
VLA-4; CXCR4; Acute lymphoblastic leukemia; Adult; Survival; Prognostic marker
Citation
LEUKEMIA RESEARCH, v.38, no.1, pp 65 - 70
Pages
6
Indexed
SCI
SCIE
SCOPUS
Journal Title
LEUKEMIA RESEARCH
Volume
38
Number
1
Start Page
65
End Page
70
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9698
DOI
10.1016/j.leukres.2013.10.016
ISSN
0145-2126
1873-5835
Abstract
Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p =0.01) and overall survival (p = 0.04) and patients with low VLA-4 expression had shorter disease-free survival (p = 0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis. (C) 2013 Elsevier Ltd. All rights reserved.
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Ko, Sun Young
Ansan Hospital (Department of Laboratory Medicine, Ansan Hospital)
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