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Cited 12 time in webofscience Cited 11 time in scopus
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Efficacy and Safety of Tenofovir-Based Rescue Therapy for Chronic Hepatitis B Patients with Previous Nucleo(s/t)ide Treatment Failure

Authors
Lee, Cho I.Kwon, So YoungKim, Jeong HanChoe, Won HyeokLee, Chang HongYoon, Eileen L.Yeon, Jong EunByun, Kwan SooKim, Yun SooKim, Ju Hyun
Issue Date
Jan-2014
Publisher
거트앤리버 발행위원회
Keywords
Antiviral agents; Treatment outcome; Hepatitis B; Resistance; Tenofovir
Citation
Gut and Liver, v.8, no.1, pp 64 - 69
Pages
6
Indexed
SCIE
SCOPUS
KCI
Journal Title
Gut and Liver
Volume
8
Number
1
Start Page
64
End Page
69
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9723
DOI
10.5009/gnl.2014.8.1.64
ISSN
1976-2283
2005-1212
Abstract
Background/Aims We investigated the efficacy and safety of tenofovir disoproxil fumarate (TDF)-based treatment in chronic hepatitis B (CHB) patients who failed previous antiviral therapies. Methods Seventeen patients who failed to achieve virological responses during sequential antiviral treatments were included. The patients were treated with TDF monotherapy (four patients) or a combination of TDF and lamivudine (13 patients) for a median of 42 months. Hepatitis B virus (HBV) DNA and hepatitis B e antigen (HBeAg) were measured, and renal function was also monitored. Results Prior to TDF therapy, 180 M, 204 I/V/S, 181 T/V, 236 T, and 184 L mutations were detected. After TDF therapy, the median HBV DNA level decreased from 4.6 log10 IU/mL to 2.0 log10 IU/mL and to 1.6 log10 IU/mL at 12 and 24 months, respectively. HBV DNA became undetectable (≤20 IU/mL) in 14.3%, 41.7%, and 100% of patients after 12, 24, and 48 months of treatment, respectively. HBeAg loss was observed in two patients. Viral breakthrough occurred in five patients who had skipped their medication. No significant changes in renal function were observed. Conclusions TDF-based rescue treatment is effective in reducing HBV DNA levels and is safe for patients with CHB who failed prior antiviral treatments. Patients' adherence to medication is related to viral rebound.
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Byun, Kwan Soo
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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