Detailed Information

Cited 0 time in webofscience Cited 61 time in scopus
Metadata Downloads

Experimental models of pancreatitis

Authors
Hyun J.J.Lee H.S.
Issue Date
2014
Publisher
Korean Society of Gastrointestinal Endoscopy
Keywords
Animal; Experiment; Models; Pancreatitis
Citation
Clinical Endoscopy, v.47, no.3, pp 212 - 216
Pages
5
Indexed
SCOPUS
KCI
Journal Title
Clinical Endoscopy
Volume
47
Number
3
Start Page
212
End Page
216
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9927
DOI
10.5946/ce.2014.47.3.212
ISSN
2234-2400
2234-2443
Abstract
Acute pancreatitis is an inflammatory disease characterized by interstitial edema, inflammatory cell infiltration, and acinar cell necrosis, depending on its severity. Regardless of the extent of tissue injury, acute pancreatitis is a completely reversible process with evident normal tissue architecture after recovery. Its pathogenic mechanism has been known to be closely related to intracellular digestive enzyme activation. In contrast to acute pancreatitis, chronic pancreatitis is characterized by irreversible tissue damage such as acinar cell atrophy and pancreatic fibrosis that results in exocrine and endocrine insufficiency. Recently, many studies of chronic pancreatitis have been prompted by the discovery of the pancreatic stellate cell, which has been identified and distinguished as the key effector cell of pancreatic fibrosis. However, investigations into the pathogenesis and treatment of pancreatitis face many obstacles because of its anatomical location and disparate clinical course. Due to these difficulties, most of our knowledge on pancreatitis is based on research conducted using experimental models of pancreatitis. In this review, several experimental models of pancreatitis will be discussed in terms of technique, advantages, and limitations. © 2014 Korean Society of Gastrointestinal Endoscopy.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Hyun, Jong Jin photo

Hyun, Jong Jin
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE