Serotonin-Related Polymorphisms in TPH1 and HTR5A Genes Are Not Associated with Escitalopram Treatment Response in Korean Patients with Major Depression
- Authors
- Kim, Yong-Gu; Chang, Hun-Soo; Won, Eun-Soo; Ham, Byung-Joo; Lee, Min-Soo
- Issue Date
- 2014
- Publisher
- KARGER
- Keywords
- Tryptophan hydroxylase-1; Serotonin 5A receptor; Major depressive disorder; Escitalopram treatment response
- Citation
- NEUROPSYCHOBIOLOGY, v.69, no.4, pp 210 - 219
- Pages
- 10
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- NEUROPSYCHOBIOLOGY
- Volume
- 69
- Number
- 4
- Start Page
- 210
- End Page
- 219
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9996
- DOI
- 10.1159/000362241
- ISSN
- 0302-282X
1423-0224
- Abstract
- Background/Aims: The genetic variations in serotonin-related genes may be associated with antidepressant treatment response in major depressive disorder (MDD). The tryptophan hydroxylase-1 (TPH1) gene and serotonin 5A receptor (HTR5A) gene are known to be involved in serotonin biosynthesis and signal transduction, respectively. The purpose of this study was to investigate a possible interaction between the TPH1 gene and the HTR5A gene in the treatment outcome of escitalopram in MDD. Methods: In total, 245 patients diagnosed with MDD were recruited, and their symptoms were evaluated using the 17-item Hamilton Depression Rating scale (HAMD-17). The association between the TPH1 218A/C and HTR5A 12A/T polymorphisms and the clinical outcomes (remission, response and changes in HAMD-17 score) was investigated after 2, 4 and 8 weeks of escitalopram treatment using multiple logistic regression or multiple linear regression analysis. Results: No significant associations of TPH1 or HTR5A gene polymorphisms were observed with either response rate or remission rate at 2,4 and 8 weeks after escitalopram treatment. In addition, the gene-gene interaction between TPH1 and HTR5A genes was not associated with the treatment outcome. Conclusions: Our results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression. (C) 2014 S. Karger AG, Basel
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Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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