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Preclinical testing of an anal bulking agent coated with a zwitterionic polymer in a fecal incontinence rat model

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dc.contributor.authorChoi, Jung-Woo-
dc.contributor.authorLee, Joonbum-
dc.contributor.authorLee, Yuseon-
dc.contributor.authorSeo, Ji-Hun-
dc.contributor.authorHong, Kwang Dae-
dc.date.accessioned2022-03-07T02:40:15Z-
dc.date.available2022-03-07T02:40:15Z-
dc.date.issued2022-04-
dc.identifier.issn2050-750X-
dc.identifier.issn2050-7518-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55337-
dc.description.abstractFecal incontinence is a disabling condition in which the passage of fecal material cannot be controlled. Although the condition is not life-threatening, it can seriously reduce the quality of life of a patient by isolating them from others. Though various surgical treatments are available for moderate to severe symptoms, a bulking agent is a minimally invasive technique that has attracted attention because of its safety and simple treatment process. However, the biocompatibility of bulking agent materials remains a central issue, with their durability questioned because immune responses and/or the circulatory system may remove the bulking agent in vivo. This study investigated a bulking agent composed of polydimethylsiloxane and hyaluronic acid as a microfiller and carrier gel, respectively. To improve the injectability of the bulking agent, the filler size was tuned using a suspension-based fabrication technique. To evade immune responses, the filler surface was treated with a zwitterionic polymer that simultaneously functionalized and stabilized the material interfaces. The resulting bulking agent exhibited good injectability and biocompatibility in vitro, with 58% lower protein adsorption and no cytotoxicity, leading to an improved bulking effect in a preclinical rat model compared with a bulking agent without surface treatment. These results illustrate the promising potential of bulking agents as a therapy for fecal incontinence with reduced foreign body reactions and long-lasting efficacy.-
dc.format.extent11-
dc.language영어-
dc.language.isoENG-
dc.publisherRoyal Society of Chemistry-
dc.titlePreclinical testing of an anal bulking agent coated with a zwitterionic polymer in a fecal incontinence rat model-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1039/d1tb02341a-
dc.identifier.scopusid2-s2.0-85128245390-
dc.identifier.wosid000754042100001-
dc.identifier.bibliographicCitationJournal of Materials Chemistry B, v.10, no.14, pp 2708 - 2718-
dc.citation.titleJournal of Materials Chemistry B-
dc.citation.volume10-
dc.citation.number14-
dc.citation.startPage2708-
dc.citation.endPage2718-
dc.type.docTypeArticle; Early Access-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.subject.keywordPlusPARTICLE-SIZE DISTRIBUTION-
dc.subject.keywordPlusSUSPENSION-
dc.subject.keywordPlusSPHINCTER-
dc.subject.keywordPlusINJECTION-
dc.subject.keywordPlusIMPLANTS-
dc.subject.keywordPlusSURFACES-
dc.subject.keywordPlusGEL-
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2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
2. Clinical Science > Department of Pathology > 1. Journal Articles

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Hong, Kwang Dae
Ansan Hospital (Department of Colon and Rectal Surgery, Ansan Hospital)
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