Detailed Information

Cited 5 time in webofscience Cited 7 time in scopus
Metadata Downloads

Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions

Authors
Kim, SunwonLee, Jong-SeokKim, Yong-HyunKim, Jin-SeokLim, Sang-YupKim, Seong HwanKim, MinjungAhn, Jeong-CheonSong, Woo-Hyuk
Issue Date
Jan-2022
Publisher
MDPI AG
Keywords
drug-coated balloon; de novo lesion; vasospasm; coronary vasomotor function
Citation
Journal of Clinical Medicine, v.11, no.2
Indexed
SCIE
SCOPUS
Journal Title
Journal of Clinical Medicine
Volume
11
Number
2
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55345
DOI
10.3390/jcm11020299
ISSN
2077-0383
2077-0383
Abstract
Balloon-injured coronary segments are known to harbor abnormal vasomotion. We evaluated whether de novo coronary lesions treated using drug-coated balloon (DCB) are prone to vasospasm and how they respond to ergonovine and nitrate. Among 132 DCB angioplasty recipients followed, 89 patients underwent ergonovine provocation test at 6-9 months follow-up. Within-subject ergonovine- and nitrate-induced diameter changes were compared among three different sites: DCB-treated vs. angiographically normal vs. segment showing prominent vasoreactivity (spastic). No patient experienced clinically refractory vasospastic angina or symptom-driven revascularization during follow-up. Ergonovine induced vasospasm in seven patients; all were multifocal spasm either involving (n = 2) or rather sparing DCB-treated segments (n = 5). None showed focal spasm that exclusively involved DCB-treated lesions. Among 27 patients with vasospastic features, DCB-treated segments showed less vasoconstriction than spastic counterparts (p < 0.001). A total of 110 DCB-treated lesions were analyzed to assess vasomotor function. Vasomotor function, defined as a combined constrictor and dilator response, was comparable between DCB-treated and angiographically normal segments (p = 0.173), while significant differences were observed against spastic counterparts (p < 0.001). In our study, DCB-treated lesions were not particularly vulnerable to vasospasm and were found to have vasomotor function similar to angiographically normal segments, supporting safety of DCB-only strategy in treating de novo native coronary lesions.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Cardiology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Jong Seok photo

Lee, Jong Seok
Ansan Hospital (Department of Cardiology, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE