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The effect of periodontitis on recipient outcomes after kidney transplantation

Authors
민현진박정수Yang JaeseokYang JihyunOh Se Won조상경조원용권준교정철웅설양조박신영김명규
Issue Date
Jan-2022
Publisher
대한신장학회
Keywords
Cardiovascular diseases; Graft rejection; Kidney transplantation; Periodontitis
Citation
Kidney Research and Clinical Practice, v.41, no.1, pp.114 - 123
Indexed
SCIE
SCOPUS
KCI
Journal Title
Kidney Research and Clinical Practice
Volume
41
Number
1
Start Page
114
End Page
123
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55426
DOI
10.23876/j.krcp.21.097
ISSN
2211-9132
Abstract
Background: Recent several reports have demonstrated that periodontitis is prevalent and adversely affects the survival in patients with chronic kidney disease (CKD) or end-stage kidney disease. However, its impact on transplant outcomes remains uncertain. Methods: This retrospective cohort study included 136 and 167 patients, respectively, who underwent living donor kidney transplantation (KT) at Seoul National University Hospital from July 2012 to August 2016 and Korea University Hospital from April 2008 to October 2018. We divided patients into three groups according to stages of periodontitis based on a new classification system. Results: Patients with severe periodontitis were older, had a higher prevalence of diabetes, a higher body mass index and C-reactive protein level, a lower cardiac output, and were more likely to be smokers, indicating its association with chronic systemic inflammation. After KT, stage IV periodontitis was independently associated with a lower incidence of acute T cell-mediated rejection, suggesting the possible effect of periodontitis on immune function. However, 1-year and 3-year estimated glomerular filtration rates were not different. Among the KT recipients followed up more than 3 years, new-onset cardiovascular disease occurred in nine patients, and coronary artery disease occurred more frequently in patients with stage IV periodontitis. However, diabetes was the independent predictor of new-onset coronary artery disease in multivariate logistic regression analysis. Conclusion: Our findings showed that periodontitis might be an important player in determining posttransplant outcomes in recipients. Further interventional trials to test whether treating periodontitis could modify transplant outcome are needed.
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2. Clinical Science > Department of Transplantation and Vascular Surgery > 1. Journal Articles
2. Clinical Science > Department of Periodontology > 1. Journal Articles
2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles

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Jung, Cheol Woong
Anam Hospital (Department of Transplantation and Vascular Surgery, Anam Hospital)
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