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Development of the Korea-Polyenvironmental Risk Score for Psychosis

Authors
Jeon, Eun-JinKang, Shi-HyunPiao, Yan-HongKim, Sung-WanKim, Jung-JinLee, Bong-JuYu, Je-ChunLee, Kyu-YoungWon, Seung-HeeLee, Seung-HwanKim, Seung-HyunKim, Eui-TaeKim, Clara TammyOliver, DominicFusar-Poli, PaoloRami, Fatima ZahraChung, Young-Chul
Issue Date
Mar-2022
Publisher
대한신경정신의학회
Keywords
Polyenvironmental risk factor; Psychosis; Prediction
Citation
Psychiatry Investigation, v.19, no.3, pp.197 - 206
Indexed
SCIE
SSCI
SCOPUS
KCI
Journal Title
Psychiatry Investigation
Volume
19
Number
3
Start Page
197
End Page
206
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55603
DOI
10.30773/pi.2021.0328
ISSN
1738-3684
Abstract
Objective Comprehensive understanding of polyenvironmental risk factors for the development of psychosis is important. Based on a review of related evidence, we developed the Korea Polyenvironmental Risk Score (K-PERS) for psychosis. We investigated whether the K-PERS can differentiate patients with schizophrenia spectrum disorders (SSDs) from healthy controls (HCs). Methods We reviewed existing tools for measuring polyenvironmental risk factors for psychosis, including the Maudsley Environmen-tal Risk Score (ERS), polyenviromic risk score (PERS), and Psychosis Polyrisk Score (PPS). Using odds ratios and relative risks for West-ern studies and the "population proportion" (PP) of risk factors for Korean data, we developed the K-PERS, and compared the scores thereon between patients with SSDs and HCs. In addition, correlation was performed between the K-PERS and Positive and Negative Syndrome Scale (PANSS). Results We first constructed the "K-PERS-I," comprising five factors based on the PPS, and then the "K-PERS-II" comprising six fac-tors based on the ERS. The instruments accurately predicted participants' status (case vs. control). In addition, the K-PERS-I and-II scores exhibited significant negative correlations with the negative symptom factor score of the PANSS. Conclusion The K-PERS is the first comprehensive tool developed based on PP data obtained from Korean studies that measures polyenvironmental risk factors for psychosis. Using pilot data, the K-PERS predicted patient status (SSD vs. HC). Further research is warranted to examine the relationship of K-PERS scores with clinical outcomes of psychosis and schizophrenia. Psychiatry Investig 2022;19(3):197-206
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Kim, Seung Hyun
Guro Hospital (Department of Psychiatry, Guro Hospital)
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