Intra-instrument channel workable, optical-resolution photoacoustic and ultrasonic mini-probe system for gastrointestinal endoscopy
- Kim, Minjae; Lee, Kang Won; Kim, KiSik; Gulenko, Oleksandra; Lee, Cheol; Keum, Bora; Chun, Hoon Jai; Choi, Hyuk Soon; Kim, Chae Un; Yang, Joon-Mo
- Issue Date
- Elsevier GmbH
- Photoacoustic endoscopy; Endoscopic ultrasound; Video endoscope; Instrument channel; Swine esophagogastric junction; Rat colorectum; Vasculature hierarchism
- Photoacoustics, v.26
- Journal Title
- There has been a long-standing expectation that the optical-resolution embodiment of photoacoustic tomography could have a substantial impact on gastrointestinal endoscopy by enabling microscopic visualization of the vasculature based on the endogenous contrast mechanism. Although multiple studies have demonstrated the in vivo imaging capability of a developed imaging device over the last decade, the implementation of such an endoscopic system that can be applied immediately when necessary via the instrument channel of a video endoscope has been a challenge. In this study, we developed a 3.38-mm diameter catheter-based, integrated optical-resolution photoacoustic and ultrasonic mini-probe system and successfully demonstrated its intrainstrument channel workability for the standard 3.7-mm diameter instrument channel of a clinical video endoscope based on a swine model. Through the instrument channel, we acquired the first in vivo dual-mode photoacoustic and ultrasonic endoscopic images from the esophagogastric junction of a swine. Further, in a rat colorectum in vivo imaging experiment, we visualized hierarchically developed mesh-like capillary networks with a hole size as small as ~50 mu m, which suggests the potential level of image details that could be photo acoustically provided in clinical settings in the future.
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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