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Effect of Fibronectin on Cervical Excision and Lipopolysaccharide-Induced Inflammation-Related Preterm Delivery

Authors
Wang, Eun-JinKim, JayKim, Ho YeonCho, Geum JoonHong, Soon CheolOh, Min-JeongKim, Hai-JoongAhn, Ki Hoon
Issue Date
Sep-2022
Publisher
SAGE Publications
Keywords
Preterm birth; Plasma fibronectin; Preterm mouse model; Cervical excision; Wound healing
Citation
Reproductive Sciences, v.29, no.9, pp.2674 - 2684
Indexed
SCIE
SCOPUS
Journal Title
Reproductive Sciences
Volume
29
Number
9
Start Page
2674
End Page
2684
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55666
DOI
10.1007/s43032-022-00936-9
ISSN
1933-7191
Abstract
In our previous study, preterm birth after pre-pregnancy partial cervical excision demonstrated abnormal wound healing with an increased muscle-to-collagen ratio at the proximal site of the cervix. We aimed to investigate whether treatment with plasma fibronectin affects the differentiation of mouse uterine cervical fibroblasts into myofibroblasts and mediates a reduction in the incidence of preterm delivery in mice. We examined the gestational period after the administration of lipopolysaccharide in mice subjected to cervical excision and subsequently treated with fibronectin or vehicle. We confirmed that the gestational period was longer in the plasma fibronectin-treated group than in the vehicle-treated control group. In addition, the ratio of a-smooth muscle actin to collagen type I alpha 1 increased after LPS injection in mice subjected to cervical excision, and this increase was suppressed by plasma fibronectin treatment. Plasma fibronectin may serve as a potential therapeutic agent to prevent preterm delivery by inhibiting myogenic differentiation in the cervix.
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Cho, Geum Joon
Guro Hospital (Department of Obstetrics and Gynecology, Guro Hospital)
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