Detailed Information

Cited 5 time in webofscience Cited 4 time in scopus
Metadata Downloads

Monitoring Wound Healing with Topically Applied Optical NanoFlare mRNA Nanosensorsopen access

Authors
Hwang, JangsunSeo, YoungminJeong, DaunNing, XiaoyuWiraja, ChristianYang, LixiaTan, Chew TengLee, JinhyuckKim, YesolKim, Ji WonKim, Dai HyunChoi, JonghoonLim, Chin YanPu, KanyiJang, Woo YoungXu, Chenjie
Issue Date
Jun-2022
Publisher
Wiley-VCH Verlag
Keywords
diabetic wound; mRNA nanosensors; NanoFlare; spherical nucleic acids; wound healing
Citation
Advanced Science, v.9, no.18
Indexed
SCIE
SCOPUS
Journal Title
Advanced Science
Volume
9
Number
18
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55704
DOI
10.1002/advs.202104835
ISSN
2198-3844
2198-3844
Abstract
An effective wound management strategy needs accurate assessment of wound status throughout the whole healing process. This can be achieved by examining molecular biomarkers including proteins, DNAs, and RNAs. However, existing methods for quantifying these biomarkers such as immunohistochemistry and quantitative polymerase chain reaction are usually laborious, resource-intensive, and disruptive. This article reports the development and utilization of mRNA nanosensors (i.e., NanoFlare) that are topically applied on cutaneous wounds to reveal the healing status through targeted and semi-quantitative examination of the mRNA biomarkers in skin cells. In 2D and 3D in vitro models, the efficacy and efficiency of these nanosensors are demonstrated in revealing the dynamic changes of mRNA biomarkers for different stages of wound development. In mouse models, this platform permits the tracking and identification of wound healing stages and a normal and diabetic wound healing process by wound healing index in real time.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Orthopedic Surgery > 1. Journal Articles
2. Clinical Science > Department of Dermatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jang, Woo Young photo

Jang, Woo Young
Anam Hospital (Department of Orthopedic Surgery, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE