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FIB-4 index and liver fibrosis are risk factors for long-term outcomes in atrial fibrillation-related stroke

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dc.contributor.authorKim, Tae Hyung-
dc.contributor.authorKim, Seung Young-
dc.contributor.authorJung, Young Kul-
dc.contributor.authorYim, Hyung Joon-
dc.contributor.authorJung, Jin-Man-
dc.contributor.authorSeo, Woo-Keun-
dc.date.accessioned2022-05-30T02:40:13Z-
dc.date.available2022-05-30T02:40:13Z-
dc.date.created2022-05-30-
dc.date.issued2022-06-
dc.identifier.issn0303-8467-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/60917-
dc.description.abstractObjective Liver fibrosis (LF) is associated with a poor prognosis in patients with ischemic stroke (IS). We aimed to assess whether LF affects long-term outcomes in patients with atrial fibrillation-related stroke or such effects vary according to sex. Methods We conducted a multicenter prospective cohort study of Korean patients with atrial fibrillation-related IS. We calculated the fibrosis-4 (FIB-4) index, and LF degree was categorized into two groups (non-advanced vs. advanced) based on the FIB-4 index. Recurrent IS, major adverse cardiac events (MACEs), and all-cause mortality were evaluated using Cox proportional hazard model. Results A total of 2897 patients were included; the median age was 75 (interquartile range 68–80) years, and 51.8% were men. The median follow-up period was 16.3 months. Of these patients, 23% had advanced LF indicated by FIB-4 index. Multivariable analysis in all populations demonstrated that the FIB-4 index and advanced LF were significantly associated with MACEs and all-cause mortality but not with recurrent IS. Furthermore, a sex disparity was observed in the outcomes of the patients. A high FIB-4 index in men was a significant predictor of recurrent IS [subdistribution hazard ratio (95% confidence interval): 1.08 (1.02–1.14)]. However, the significance of advanced LF disappeared in MACEs in women and in all-cause mortality in men. Conclusion The FIB-4 index and advanced LF indicated by FIB-4 index are independent prognostic factors for long-term outcomes in Asian patients with atrial fibrillation-related IS. However, these predictors may contribute differently to patient outcomes depending on the sex.-
dc.language영어-
dc.language.isoen-
dc.publisherElsevier BV-
dc.titleFIB-4 index and liver fibrosis are risk factors for long-term outcomes in atrial fibrillation-related stroke-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Tae Hyung-
dc.contributor.affiliatedAuthorKim, Seung Young-
dc.contributor.affiliatedAuthorJung, Young Kul-
dc.contributor.affiliatedAuthorYim, Hyung Joon-
dc.contributor.affiliatedAuthorJung, Jin-Man-
dc.identifier.doi10.1016/j.clineuro.2022.107235-
dc.identifier.scopusid2-s2.0-85127934221-
dc.identifier.wosid000793726000001-
dc.identifier.bibliographicCitationClinical Neurology and Neurosurgery, v.217-
dc.relation.isPartOfClinical Neurology and Neurosurgery-
dc.citation.titleClinical Neurology and Neurosurgery-
dc.citation.volume217-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalResearchAreaSurgery-
dc.relation.journalWebOfScienceCategoryClinical Neurology-
dc.relation.journalWebOfScienceCategorySurgery-
dc.subject.keywordPlusSOLUBLE EPOXIDE HYDROLASE-
dc.subject.keywordPlusPREDICTING STROKE-
dc.subject.keywordPlusPREVENTION-
dc.subject.keywordAuthorAtrial fibrillation-
dc.subject.keywordAuthorStroke-
dc.subject.keywordAuthorLiver fibrosis-
dc.subject.keywordAuthorPrognosis-
dc.subject.keywordAuthorSex-
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2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Kim, Seung Young
안산병원 (Department of Gastroenterology and Hepatology, Ansan Hospital)
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