FIB-4 index and liver fibrosis are risk factors for long-term outcomes in atrial fibrillation-related stroke
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Hyung | - |
dc.contributor.author | Kim, Seung Young | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Jung, Jin-Man | - |
dc.contributor.author | Seo, Woo-Keun | - |
dc.date.accessioned | 2022-05-30T02:40:13Z | - |
dc.date.available | 2022-05-30T02:40:13Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 0303-8467 | - |
dc.identifier.issn | 1872-6968 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/60917 | - |
dc.description.abstract | Objective Liver fibrosis (LF) is associated with a poor prognosis in patients with ischemic stroke (IS). We aimed to assess whether LF affects long-term outcomes in patients with atrial fibrillation-related stroke or such effects vary according to sex. Methods We conducted a multicenter prospective cohort study of Korean patients with atrial fibrillation-related IS. We calculated the fibrosis-4 (FIB-4) index, and LF degree was categorized into two groups (non-advanced vs. advanced) based on the FIB-4 index. Recurrent IS, major adverse cardiac events (MACEs), and all-cause mortality were evaluated using Cox proportional hazard model. Results A total of 2897 patients were included; the median age was 75 (interquartile range 68–80) years, and 51.8% were men. The median follow-up period was 16.3 months. Of these patients, 23% had advanced LF indicated by FIB-4 index. Multivariable analysis in all populations demonstrated that the FIB-4 index and advanced LF were significantly associated with MACEs and all-cause mortality but not with recurrent IS. Furthermore, a sex disparity was observed in the outcomes of the patients. A high FIB-4 index in men was a significant predictor of recurrent IS [subdistribution hazard ratio (95% confidence interval): 1.08 (1.02–1.14)]. However, the significance of advanced LF disappeared in MACEs in women and in all-cause mortality in men. Conclusion The FIB-4 index and advanced LF indicated by FIB-4 index are independent prognostic factors for long-term outcomes in Asian patients with atrial fibrillation-related IS. However, these predictors may contribute differently to patient outcomes depending on the sex. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | FIB-4 index and liver fibrosis are risk factors for long-term outcomes in atrial fibrillation-related stroke | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.clineuro.2022.107235 | - |
dc.identifier.scopusid | 2-s2.0-85127934221 | - |
dc.identifier.wosid | 000793726000001 | - |
dc.identifier.bibliographicCitation | Clinical Neurology and Neurosurgery, v.217 | - |
dc.citation.title | Clinical Neurology and Neurosurgery | - |
dc.citation.volume | 217 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | SOLUBLE EPOXIDE HYDROLASE | - |
dc.subject.keywordPlus | PREDICTING STROKE | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordAuthor | Atrial fibrillation | - |
dc.subject.keywordAuthor | Stroke | - |
dc.subject.keywordAuthor | Liver fibrosis | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Sex | - |
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