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Cited 31 time in webofscience Cited 31 time in scopus
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BNT162b2-induced memory T cells respond to the Omicron variant with preserved polyfunctionality

Authors
Jung, Min KyungJeong, Seong DongNoh, Ji YunKim, Dong-UkJung, SungminSong, Joon YoungJeong, Hye WonPark, Su-HyungShin, Eui-Cheol
Issue Date
Jun-2022
Publisher
NATURE PUBLISHING GROUP
Citation
Nature Microbiology, v.7, no.6, pp 909 - 917
Pages
9
Indexed
SCIE
SCOPUS
Journal Title
Nature Microbiology
Volume
7
Number
6
Start Page
909
End Page
917
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/60986
DOI
10.1038/s41564-022-01123-x
ISSN
2058-5276
2058-5276
Abstract
An analysis of memory T cells induced by messenger RNA vaccination reveals that they maintain polyfunctionality in response to the Omicron spike protein. The Omicron variant (B.1.1.529) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) extensively escapes neutralizing antibodies elicited by SARS-CoV-2 infection or vaccination. In the present study, we investigated whether BNT162b2 messenger RNA vaccine-induced memory T cells functionally respond to the Omicron spike protein. Experiments were performed using samples from healthcare workers who were immunized with two or three doses of the BNT162b2 mRNA vaccine and individuals with prior SARS-CoV-2 infection who were immunized with two doses of the BNT162b2 vaccine. Vaccine-induced memory T cells exhibited substantial responses to the Omicron spike protein, with no difference between healthcare workers with two versus three vaccine doses. In individuals with prior infection, two-dose vaccination robustly boosted memory T cells that responded to the Omicron spike protein and the SARS-CoV-2 wild-type (lineage B) spike protein. Importantly, polyfunctionality was preserved in vaccine-induced memory T cells responding to the Omicron spike protein. The present findings indicate that BNT162b2-induced memory T cells substantially respond to the Omicron variant with preserved polyfunctionality.
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Noh, Ji Yun
Guro Hospital (Department of Infectious Diseases, Guro Hospital)
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