Postmortem gene expression profiles in the habenulae of suicides: implication of endothelial dysfunction in the neurovascular system
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Yoo, Hyeijung | - |
dc.contributor.author | Kim, Ji Yeon | - |
dc.contributor.author | Yang, Soo Hyun | - |
dc.contributor.author | Lee, Hyun Woo | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Son, Gi Hoon | - |
dc.contributor.author | Kim, Hyun | - |
dc.date.accessioned | 2022-06-14T00:40:22Z | - |
dc.date.available | 2022-06-14T00:40:22Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61010 | - |
dc.description.abstract | The habenula (Hb) is an epithalamic structure that links multiple forebrain areas with the mid/hindbrain monoaminergic systems. As an anti-reward center, it has been implicated in the etiology of various neuropsychiatric disorders, particularly those associated with dysregulated reward circuitry. In this regard, Hb has been proposed as a therapeutic target for treatment-resistant depression associated with a higher risk of suicide. Therefore, we aimed to gain insight into the molecular signatures of the Hb in association with suicide in individuals with major depression. Postmortem gene expression analysis identified 251 differentially expressed genes (DEGs) in the Hb tissue of suicides in comparison with Hb tissues from neurotypical individuals. Subsequent bioinformatic analyses using single-cell transcriptome data from the mouse Hb showed that the levels of a subset of endothelial cell-enriched genes encoding cell-cell junctional complex and plasma membrane-associated proteins, as well as the levels of their putative upstream transcriptional regulators, were significantly affected in suicides. Although our findings are based on a limited number of samples, the present study suggests a potential association of endothelial dysfunction in the Hb with depression and suicidal behavior. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BioMed Central | - |
dc.title | Postmortem gene expression profiles in the habenulae of suicides: implication of endothelial dysfunction in the neurovascular system | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/s13041-022-00934-7 | - |
dc.identifier.scopusid | 2-s2.0-85131106723 | - |
dc.identifier.wosid | 000801845200001 | - |
dc.identifier.bibliographicCitation | Molecular Brain, v.15, no.1 | - |
dc.citation.title | Molecular Brain | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | LATERAL HABENULA | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Suicide | - |
dc.subject.keywordAuthor | Habenula | - |
dc.subject.keywordAuthor | Postmortem | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.subject.keywordAuthor | Transcriptome | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.