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ABC: a novel algorithm to stratify decompensation risk in patients with compensated advanced chronic liver disease (CHESS2108): an international, multicenter cohort study

Authors
Liu, ChuanLi, JiaWong, Yu JunXie, QingHirooka, MasashiEnomoto, HirayukiKim, Tae HyungHanafy, Amr ShaabanHe, RuilingKoizumi, YoheiHiasa, YoichiNishimura, TakashiIijima, HirokoJung, Young KulYim, Hyung JoonMa, JianzhongZeng, Qing-LeiSarin, Shiv KumarQi, Xiaolong
Issue Date
May-2022
Publisher
Springer Pub. Co.
Keywords
Baveno VI criteria; Liver stiffness; Clinically significant portal hypertension; Hepatic decompensation; Compensated advanced chronic liver disease; Hepatic venous pressure gradient
Citation
Hepatology International
Indexed
SCIE
SCOPUS
Journal Title
Hepatology International
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61036
DOI
10.1007/s12072-022-10345-4
ISSN
1936-0533
Abstract
Background Liver-related death is preceded by clinical decompensation; therefore, the risk stratification of decompensation in compensated advanced chronic liver disease (cACLD) is extraordinary significant. Methods The international, multicenter study included three cohorts from January 2009 to August 2021. In training cohort, the unfavorable Baveno VI criteria patients were used to develop the novel CHESS criteria to stratify decompensation risk. The Algorithm based on Baveno VI criteria plus CHESS criteria (ABC model) was validated in validation cohort, and used to diagnose clinically significant portal hypertension (CSPH) in hepatic venous pressure gradient (HVPG)-performed cohort. Results A total of 1377 cACLD patients were enrolled. In training cohort, multivariate analysis revealed that liver stiffness measurement (LSM), platelet count (PLT), albumin, alanine aminotransferase (ALT) and varices were the independent risk factors for hepatic decompensation. The novel CHESS criteria was produced (0.036 × LSM [kPa]) + (− 0.013 × PLT [109/L]) + (− 0.068 × Albumin [g/L])) + (− 0.016 × ALT [U/L]) + (0.651 × Varices [present: 1, absent: 0]), and < − 4.4, − 4.4 to − 3.1 and > − 3.1 indicated the low risk, medium risk, and high risk of decompensation, with a 3 year-time-dependent area under the curve (tAUC) of 0.851 (0.800–0.901). In validation cohort, the 3 year-tAUC of ABC model was 0.843 (0.742–0.943). Notably, in HVPG cohort, the high risk group was used to rule in CSPH with a positive predictive value of 93.0%. Conclusions The ABC model can stratify the risk of decompensation in cACLD. HVPG evaluation can be waived in both low risk and high risk cACLD patients as they can be managed by Baveno VI criteria and non-selective β-blockers intervention, respectively, and the remaining medium risk patients need further HVPG evaluation.
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Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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