Effect of L-carnitine on quality of life in covert hepatic encephalopathy: a randomized, double-blind, placebo-controlled study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Eileen L. | - |
dc.contributor.author | Ahn, Sang Bong | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Cho, Yong Kyun | - |
dc.contributor.author | Song, Do Seon | - |
dc.contributor.author | Jeong, Jae Yoon | - |
dc.contributor.author | Kim, Hee Yeon | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Song, Myeong Jun | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Kim, Hyoung Su | - |
dc.contributor.author | Jeong, Soung Won | - |
dc.contributor.author | Kim, Sang Gyune | - |
dc.contributor.author | Lee, Tae Hee | - |
dc.date.accessioned | 2022-06-14T02:40:17Z | - |
dc.date.available | 2022-06-14T02:40:17Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61039 | - |
dc.description.abstract | Background/Aims L-carnitine is potentially beneficial in patients with hepatic encephalopathy (HE). We aimed to evaluate the impact of L-carnitine on the quality of life and liver function in patients with liver cirrhosis and covert HE. Methods We conducted an investigator-initiated, prospective, multi-center, double-blind, randomized phase III trial in patients with covert HE. A total of 150 patients were randomized 1:1 to L-carnitine (2 g/day) or placebo for 24 weeks. Changes in quality of life and liver function were assessed at 6 months. The model for end-stage liver disease (MELD), the 36-Item Short Form Survey (SF-36), the psychometric hepatic encephalopathy score (PHES), and the Stroop Test were evaluated in all patients. Results The total SF-36 score significantly improved in the L-carnitine group after 24 weeks (difference: median, 2; interquartile range, 0 to 11; p < 0.001); however, these values were comparable between the two groups. Furthermore, there was a significant ordinal improvement in PHES scores among patients with minimal HE who were in the L-carnitine group (p = 0.007). Changes in the total carnitine level also positively correlated with improvements in the Stroop test in the L-carnitine group (color test, r = 0.3; word test, r = 0.4; inhibition test, r = 0.5; inhibition/switching test, r = 0.3; all p < 0.05). Nevertheless, the MELD scores at week 24 did not differ between the groups. Conclusions Twenty-four weeks of L-carnitine supplementation was safe but ineffective in improving quality of life and liver function. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한내과학회 | - |
dc.title | Effect of L-carnitine on quality of life in covert hepatic encephalopathy: a randomized, double-blind, placebo-controlled study | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3904/kjim.2021.338 | - |
dc.identifier.scopusid | 2-s2.0-85134036202 | - |
dc.identifier.wosid | 000800095900001 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Internal Medicine, v.37, no.4, pp 757 - 767 | - |
dc.citation.title | The Korean Journal of Internal Medicine | - |
dc.citation.volume | 37 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 757 | - |
dc.citation.endPage | 767 | - |
dc.type.docType | Article; Early Access | - |
dc.identifier.kciid | ART002849294 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | L-ACETYLCARNITINE | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | COMA | - |
dc.subject.keywordAuthor | Carnitine | - |
dc.subject.keywordAuthor | Liver cirrhosis | - |
dc.subject.keywordAuthor | Hepatic encephalopathy | - |
dc.subject.keywordAuthor | Randomized controlled trials as topic | - |
dc.subject.keywordAuthor | Stroop test | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.