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Effect of L-carnitine on quality of life in covert hepatic encephalopathy: a randomized, double-blind, placebo-controlled study

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dc.contributor.authorYoon, Eileen L.-
dc.contributor.authorAhn, Sang Bong-
dc.contributor.authorJun, Dae Won-
dc.contributor.authorCho, Yong Kyun-
dc.contributor.authorSong, Do Seon-
dc.contributor.authorJeong, Jae Yoon-
dc.contributor.authorKim, Hee Yeon-
dc.contributor.authorJung, Young Kul-
dc.contributor.authorSong, Myeong Jun-
dc.contributor.authorKim, Sung Eun-
dc.contributor.authorKim, Hyoung Su-
dc.contributor.authorJeong, Soung Won-
dc.contributor.authorKim, Sang Gyune-
dc.contributor.authorLee, Tae Hee-
dc.date.accessioned2022-06-14T02:40:17Z-
dc.date.available2022-06-14T02:40:17Z-
dc.date.created2022-06-13-
dc.date.issued2022-07-
dc.identifier.issn1226-3303-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61039-
dc.description.abstractBackground/Aims L-carnitine is potentially beneficial in patients with hepatic encephalopathy (HE). We aimed to evaluate the impact of L-carnitine on the quality of life and liver function in patients with liver cirrhosis and covert HE. Methods We conducted an investigator-initiated, prospective, multi-center, double-blind, randomized phase III trial in patients with covert HE. A total of 150 patients were randomized 1:1 to L-carnitine (2 g/day) or placebo for 24 weeks. Changes in quality of life and liver function were assessed at 6 months. The model for end-stage liver disease (MELD), the 36-Item Short Form Survey (SF-36), the psychometric hepatic encephalopathy score (PHES), and the Stroop Test were evaluated in all patients. Results The total SF-36 score significantly improved in the L-carnitine group after 24 weeks (difference: median, 2; interquartile range, 0 to 11; p < 0.001); however, these values were comparable between the two groups. Furthermore, there was a significant ordinal improvement in PHES scores among patients with minimal HE who were in the L-carnitine group (p = 0.007). Changes in the total carnitine level also positively correlated with improvements in the Stroop test in the L-carnitine group (color test, r = 0.3; word test, r = 0.4; inhibition test, r = 0.5; inhibition/switching test, r = 0.3; all p < 0.05). Nevertheless, the MELD scores at week 24 did not differ between the groups. Conclusions Twenty-four weeks of L-carnitine supplementation was safe but ineffective in improving quality of life and liver function.-
dc.language영어-
dc.language.isoen-
dc.publisher대한내과학회-
dc.titleEffect of L-carnitine on quality of life in covert hepatic encephalopathy: a randomized, double-blind, placebo-controlled study-
dc.typeArticle-
dc.contributor.affiliatedAuthorJung, Young Kul-
dc.identifier.doi10.3904/kjim.2021.338-
dc.identifier.scopusid2-s2.0-85134036202-
dc.identifier.wosid000800095900001-
dc.identifier.bibliographicCitationThe Korean Journal of Internal Medicine, v.37, no.4, pp.757 - 767-
dc.relation.isPartOfThe Korean Journal of Internal Medicine-
dc.citation.titleThe Korean Journal of Internal Medicine-
dc.citation.volume37-
dc.citation.number4-
dc.citation.startPage757-
dc.citation.endPage767-
dc.type.rimsART-
dc.type.docTypeArticle; Early Access-
dc.identifier.kciidART002849294-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPlusL-ACETYLCARNITINE-
dc.subject.keywordPlusLIVER-DISEASE-
dc.subject.keywordPlusCOMA-
dc.subject.keywordAuthorCarnitine-
dc.subject.keywordAuthorLiver cirrhosis-
dc.subject.keywordAuthorHepatic encephalopathy-
dc.subject.keywordAuthorRandomized controlled trials as topic-
dc.subject.keywordAuthorStroop test-
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Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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